Search Results for: prostate cancer

Long Non-Coding RNAs Linked to Development and Progression of Prostate Cancer

lncRNA

from BiotechDaily International –  Cancer researchers have found a link between a number of long non-coding RNAs and the development and progression of prostate cancer. Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes lncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar ...

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Androgen-responsive lncRNAs are diagnostic and prognostic markers for prostate cancer

lncRNA

Prostate cancer (PCa) is a leading cause of mortality among males. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that may act as biomarkers and therapeutic targets. In this study, researchers at Fudan University firstly conducted analysis of global lncRNA expression patterns by using their own cohort (GSE73397) and two public available gene expression datasets: The Cancer Genome Atlas ...

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Is Long Noncoding RNA a Culprit in Prostate Cancer?

lncRNA

from Oncotherapy Network by Bryant Furlow – Noncoding RNA appears to be involved in the epigenetic regulation of prostate cancer, according to findings published in Nature Genetics. “Our research looked at genetic variations associated with prostate cancer and we found that about half of those genetic variations may function through noncoding genes rather than the protein-coding genes,” said senior study ...

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lncRNA prostate cancer associated transcript-14 (PCAT-14) is prognostic for metastatic disease and survival

lncRNA

Long noncoding RNAs (lncRNAs) are an emerging class of relatively underexplored oncogenic molecules with biological and clinical significance. Current inadequacies for stratifying patients with aggressive disease presents a strong rationale to systematically identify lncRNAs as clinical predictors in localized prostate cancer. To identify RNA biomarkers associated with aggressive prostate cancer researchers from the Washington University School of Medicine obtained radical ...

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Long Non-Coding RNA Induces Growth and Impairs Death in Prostate Cancer Cells

lncRNA

from Prostate Cancer News Today by Ines Martins –  Researchers at the University of Tokyo in Japan have shown that a long non-coding RNA (lncRNA) called a suppressor of cytokine signaling 2-antisense transcript 1 (SOCS2-AS1) may be involved in prostate cancer development by impairing cell death. lncRNAs are RNA molecules that do not code for a protein but are implicated ...

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines

lncRNA

Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and microRNAs. However, there is limited data on the role and expression of long noncoding RNAs (lncRNAs) in prostate cancer exosomes. Researchers from the ...

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Long noncoding RNA DANCR promotes invasion of prostate cancer

LncRNA DANCR suppresses differentiation of epithelial cells, however, its function in prostate cancer development is still unknown. In the present study, researchers at Xi’an Jiaotong University found the expression of DANCR increases in prostate cancer tissues and cells compared to normal prostate tissues and cells, moreover, DANCR promotes invasion and migration of prostate cancer cells in vitro and metastasis of ...

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Long non-coding RNAs harboring miRNA seed regions are enriched in prostate cancer exosomes

lncRNA

Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to be modulators of gene expression. In this study, researchers ...

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Long noncoding RNAs as putative biomarkers for prostate cancer detection

lncRNA

Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. Researchers at the Sanford-Burnham Medical Research Institute identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and ...

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