New Reference Text Published – Long Non Coding RNA Biology

In recent years, our functional understanding of the genome has changed dramatically. The discovery of pervasive transcription and the prevalence of noncoding RNAs (ncRNAs) have challenged the traditional definition of genes and what should be considered a functional region of the genome. Noncoding RNAs are defined as transcripts that do not encode proteins. Formally, this classification includes components of the translation machinery such as ribosomal RNA (rRNA) and transfer RNA (tRNA). However, the term ncRNA is also commonly used to describe other noncoding transcripts implicated in the regulation of gene expression. In particular, this category includes short regulatory ncRNAs (e.g., microRNAs, small interfering RNA) and longer transcripts about which much less is known. This book focuses on this latter class of long ncRNAs (lncRNAs). (read more…)

Pages i-xvi – Front Matter

Pages 1-46 History, Discovery, and Classification of lncRNAs
Julien Jarroux, Antonin Morillon, Marina Pinskaya

Pages 47-74 – Long Noncoding RNA: Genome Organization and Mechanism of Action
Vijay Suresh Akhade, Debosree Pal, Chandrasekhar Kanduri

Pages 75-118 – From Heterochromatin to Long Noncoding RNAs in Drosophila: Expanding the Arena of Gene Function and Regulation
Subhash C. Lakhotia

Pages 119-132 – Long Noncoding RNAs in the Yeast S. cerevisiae
Rachel O. Niederer Ph.D., Evan P. Hass, David C. Zappulla Ph.D.

Pages 133-154 – Long Noncoding RNAs in Plants
Hsiao-Lin V. Wang, Julia A. Chekanova

Pages 155-198 – Long Noncoding RNAs in Mammalian Development and Diseases
Parna Saha, Shreekant Verma, Rashmi U. Pathak, Rakesh K. Mishra

Pages 199-222 – Long Noncoding RNAs in Cancer and Therapeutic Potential
Arun Renganathan, Emanuela Felley-Bosco

Pages 223-252 – Long Noncoding RNAs in Pluripotency of Stem Cells and Cell Fate Specification
Debosree Pal, M. R. S. Rao

Pages 253-282 – Understanding the Role of lncRNAs in Nervous System Development
Brian S. Clark Ph.D., Seth Blackshaw Ph.D.

Pages 283-323 – Technological Developments in lncRNA Biology
Sonali Jathar, Vikram Kumar, Juhi Srivastava, Vidisha Tripathi

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