Long Noncoding RNAs in Metabolic Syndrome Related Disorders

Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes and by regulatory noncoding RNA (short and long noncoding RNA (ncRNA)) that are important for gene expression/transcript stability. Researchers from Jagiellonian University summarize data concerning the significance of long noncoding RNAs (lncRNAs) in metabolic syndrome related disorders, focusing on adipose tissue and pancreatic islands.

Biological role of lncRNAs


Role of lncRNAs has been implicated in the regulation of diverse processes, manifested by three ways of interactions: RNA-RNA, RNA-DNA, and RNA-protein, both in the nucleus and in the cytoplasm.

Losko M, Kotlinowski J, Jura J. (2016) Long Noncoding RNAs in Metabolic Syndrome Related Disorders. Mediators Inflamm 2016:5365209. [article]

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