Long non-coding RNAs in Plasmodium falciparum

Plasmodium falciparumNon-coding RNAs (ncRNAs) are transcribed from genes but are not translated to protein. Though, it is assumed that genetic information is processed by protein, there are evidences that a large part of the genomes of organisms and mammals are transcribed into ncRNAs. The theory that long non-coding rRNAs (lncRNAs) are significant regulators of gene expression and other transcriptional processes is strengthening as new methods continue to be developed for their identification. The discovery of lncRNAs in Plasmodium falciparum, which causes the most lethal form of human malaria, has provided insights into the mechanism by which the parasite triggers virulence, through epigenetic modification by chromatin remodelling of the var genes.

  • Adamu B. (1023) Long non-coding RNAs in Plasmodium falciparum. Cambridge Student Journal of  Genetics Edition 1. [article]

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