Long non-coding RNAs (lncRNAs) are gradually drawing the attention of the cancer research community due to their pivotal involvement in tumorigenesis and tumor progression. These non-protein coding, >200 nucleotides long transcripts are aberrantly expressed in the majority of human malignancies, including gastric cancer (GC).
The discovery that lncRNAs are severely deregulated across different human malignancies has prompted the pursuit of revealing a possible central involvement of lncRNAs in carcinogenesis. Indeed, it seems that lncRNAs influence, through epigenetic and transcriptional regulation, key events during malignant transformation and tumor progression that include apoptosis, epithelial-to-mesenchymal transition, and metastatic spread. As a result, many lncRNAs are now categorized as oncogenes (e.g., HOTAIR, ANRIL, MALAT1) or tumor suppressor genes (e.g., GAS5, MEG3, TUG1).
But how can lncRNAs affect so many biological processes of such importance? The answer is apparently simple (read more…)
PVT1 network of interactions in gastric cancer and its potential for clinical translation. Biomolecules that can be routinely measured by PCR* or immunohistochemistry