Regulation of Gene Expression by Non-coding RNAs and RNA-binding Proteins
Posted by: National Institutes of Health (NIH)
Posted date: 2014-Apr-24
We are seeking an outstanding individual for a postdoctoral position in the Integrative Immunobiology Unit (Laboratory of Immunology, NIAID). Our interests include transcriptional and post-transcriptional regulation of cellular fates in the hematopoietic and immune system under physiological and pathological situations. A main focus of the lab is to elucidate the role of microRNAs, long non-coding RNAs and RNA-binding proteins in immunity. These novel regulatory circuits are then integrated with well-known signaling and transcriptional networks to gain a better understanding of perturbations in gene expression programs that result in immunodeficiency, autoimmunity, immunopathology, cancer and infectious diseases. We are also interested in manipulations that can instead augment immunity.
Applicants should have a recent Ph.D. and/or M.D. and publications in peer-reviewed journals. Talented individuals with backgrounds in physics or computer science interested in analyzing RNA-seq and ChIP-seq datasets are encouraged to apply. The postdoctoral fellow is expected to take a multi-disciplinary approach, including genetics, biochemistry, cell biology, genomics and computational biology, towards systematically understanding how the molecular circuits in mammalian cells are wired. The incumbent must be a highly motivated, creative and independent fast learner with a strong work ethic; to have excellent organizational, writing and communication skills; and to have critical thinking abilities. Incumbent must be able to design and execute experiments in order to address important outstanding questions in biology and will ultimately lead to improvements in human health.
Please visit us on the Web at http://www3.niaid.nih.gov/labs/aboutlabs/li/iiu/. One potential project will follow up the following publication:
Yuan J, Nguyen CK, Liu X, Kanellopoulou C, Muljo SA. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science. 2012 Mar 9; 335: 1195-1200.
Qualified candidates should send their CV; statement of previous, current and future research interests and goals; and at least three references to Stefan Muljo, Ph.D., at firstname.lastname@example.org
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