|United States Patent Application
| Hoon; Dave S.B. ; et al.
|| July 11, 2013
LONG NONCODING RNA (LNCRNA) AS A BIOMARKER AND THERAPEUTIC MARKER IN CANCER
Long noncoding RNAs (lncRNAs) that may be used as cancer biomarkers and methods of diagnosing, prognosing and monitoring cancer including, but not limited to, cutaneous melanoma using said lncRNAs are provided herein. In some embodiments, the methods include steps of isolating one or more lncRNA
transcripts in a biological sample from the subject; measuring a test level of the one or more isolated lncRNA
transcripts; comparing the test level to a control level of the one or more lncRNA
transcripts; and diagnosing or making a prognosis based on the lncRNA
level. In some embodiments, the lncRNA
transcript is an linc00340 transcript or variant thereof. These lncRNA
transcripts may also be used as a therapeutic target in the treatment of cancer.