Large numbers of lincRNA (long intergenic non-coding RNA) have been detected through high-throughput sequencing technology. However, currently we still know very little about their functions. Therefore, a lincRNA function annotation database is needed to facilitate the study in this field. In this article, researchers from the Tsinghua University, China present Linc2GO, a web resource which aims to provide comprehensive functional annotations for human lincRNA. MicroRNA-mRNA as well as microRNA-lincRNA interaction data were integrated to generate lincRNA functional annotations based on the “ceRNA hypothesis”. To the author’s knowledge, Linc2GO is the first database that makes use of the “ceRNA hypothesis” to predict lincRNA functions.
AVAILABILITY – Freely available at http://www.bioinfo.tsinghua.edu.cn/~liuke/Linc2GO/index.html
- Liu K, Yan Z, Li Y, Sun Z. (2013) Linc2GO: A Human LincRNA Function Annotation Resource Based On ceRNA Hypothesis. Bioinformatics [Epub ahead of print]. [abstract]