Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, the authors focus on the current methods for analyzing lncRNA structure and expression, which is basic but necessary information for in-depth, large-scale analysis of lncRNA functions.
Zhao Y, Wang J, Chen X, Luo H, Zhao Y, Xiao Y, Chen R. (2013) Large-scale study of long non-coding RNA functions based on structure and expression features. Sci China Life Sci 56(10), 953-959. [abstract]