Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk

Accumulating evidence indicates that long noncoding RNAs (lncRNAs) contribute to autism spectrum disorder (ASD) risk. Although a few lncRNAs have long been recognized to have important functions, the vast majority of this class of molecules remains uncharacterized. Because lncRNAs are more abundant in human brain than protein-coding RNAs, it is likely that they contribute to brain disorders, including ASD. The authors review here the known functions of lncRNAs and the potential contributions of lncRNAs to ASD.

• Wilkinson B, Campbell DB. (2013) Contribution of Long Noncoding RNAs to Autism Spectrum Disorder Risk. Int Rev Neurobiol 113, 35-59. [abstract]