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Measures of co-expression for improved function prediction of long non-coding RNAs

lncrna

Almost 16,000 human long non-coding RNA (lncRNA) genes have been identified in the GENCODE project. However, the function of most of them remains to be discovered. The function of lncRNAs and other novel genes can be predicted by identifying significantly enriched annotation terms in already annotated genes that are co-expressed with the lncRNAs. However, such approaches are sensitive to the ...

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Teenage drinking lnc’ed with epigenetic changes to emotional center of brain

lncrna

From Genetic Engineering News A study of human brain tissue has found that binge drinking during adolescence causes epigenetic changes that could be linked with the development of psychological problems and alcohol use disorder (AUD) in adulthood. The study, headed by researchers at the University of Illinois at Chicago (UIC) Center for Alcohol Research in Epigenetics, discovered that the brains ...

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Are lncRNAs regulating host translation during infections?

lncRNA

Pathogenic bacteria produce powerful virulent factors, such as pore-forming toxins, that promote their survival and cause serious damage to the host. Host cells reply to membrane stresses and ionic imbalance by modifying gene expression at the epigenetic, transcriptional and translational level, to recover from the toxin attack. The fact that the majority of the human transcriptome encodes for non-coding RNAs ...

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How Defeating THOR Could Bring a Hammer Down on Cancer

Researchers have identified and characterized a new type of RNA protein called THOR that plays a role in cancer development — and could serve as a target for drug development. It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer, too. Researchers at the University of Michigan Comprehensive Cancer ...

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lncRNA HANR promotes tumorigenesis and increase of chemoresistance

lncRNA

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. In the current study, ...

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Genomic recycling: Ancestral genes take on new roles

lncrnas

One often hears about the multitude of genes we have in common with chimps, birds or other living creatures, but such comparisons are sometimes misleading. The shared percentage usually refers only to genes that encode instructions for making proteins – while overlooking regulatory genes, which nonetheless make up a large part of the genome. “Humans and fish, for instance, share ...

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