Publications

Identification of key lncRNAs in colorectal cancer progression based on associated protein–protein interaction analysis

lncRNA

Colorectal cancer (CRC) was one of the most commonly diagnosed malignancies. The molecular mechanisms involved in the progression of CRC remain unclear. Accumulating evidences showed that long noncoding RNAs (lncRNAs) played key roles in tumorigenesis, cancer progression, and metastasis. Researchers at Fudan University aimed to explore the roles of lncRNAs in the progression of CRC. In this study, the researchers aimed to ...

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Researchers hypothesize that the prostate-specific lncRNA PCA3 has been introduced into the human genome by an ancient virus

Prostate cancer, the most frequent type of cancer in men, is surpassed only by lung cancer in causing cancer-related death. Despite major progress in defining the mutational landscape of this tumor, its etiology remains obscure. The intronic long-noncoding RNA (lncRNA) PCA3 is a specific marker of prostate cancer that acts as a trans-dominant negative oncogene to down-regulate the tumor suppressor ...

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Plasma lncRNA HOTAIR could serve as a promising biomarker for diagnosing and monitoring NSCLC

lncrna

Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense RNA (HOTAIR) has been reported to play a vital role in various cancers. It has been found that HOTAIR was upregulated in non-small cell lung cancer (NSCLC) and involved in cell invasion and metastasis. The aberrant expression of HOTAIR is expected to serve as a potential biomarker for patients with NSCLC. ...

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Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

lncRNA

Although numerous long non-coding RNAs (lncRNAs) have been identified to be important in human cancer, their potential regulatory roles in epithelial tumorigenesis and tumor progression in ovarian cancer remain unclear. Researchers from Nanjing Medical University set out to investigate lncRNAs that were differentially expressed (DE) in epithelial ovarian cancer and to explore their potential functions. The lncRNA profiles in five pairs ...

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Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression

lncRNA

Triple negative breast cancer (TNBC) is non-responsive to conventional anti-hormonal and Her2 targeted therapies, making it necessary to identify new molecular targets for therapy. Long non-coding RNA anti-differentiation ncRNA (lncRNA DANCR) was identified in participating carcinogenesis of hepatocellular carcinoma, but its expression and potential role in TNBC progression is still unclear. In the present study, Researchers from Peking University Health Science ...

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Comprehensive discovery of non-coding RNAs in acute myeloid leukemia cell transcriptomes

lncRNA

To comprehensively detect diverse and novel RNA species, researchers from Washington University, St. Louis compared deep small RNA and RNA sequencing (RNA-seq) methods applied to a primary acute myeloid leukemia (AML) sample. They were able to discover previously unannotated small RNAs using deep sequencing of a library method employing broader insert size selection. The researchers analyzed the long non-coding RNA (lncRNA) ...

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lncRNA GAS5 and the efficacy of steroids

lncRNA

Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant number of side effects, that are particularly severe in paediatric patients, the identification of subjects that are most likely ...

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Identification of four prognostic lncRNAs for survival prediction of patients with hepatocellular carcinoma

lncRNA

As the fifth most common cancer worldwide, Hepatocellular carcinoma (HCC) is also the third most common cause of cancer-related death in China. Several lncRNAs have been demonstrated to be associated with occurrence and prognosis of HCC. However, identification of prognostic lncRNA signature for HCC with expression profiling data has not been conducted yet. With the reuse of public available TCGA ...

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Neat1 is a p53-inducible lincRNA essential for transformation suppression

lncrna

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, researchers at Stanford University School of Medicine leveraged p53 ChIP-seq (chromatin immunoprecipitation [ChIP] combined with high-throughput sequencing) and RNA-seq ...

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The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these molecules in cardiac fibrosis is limited. Using an integrated genomic screen, researchers at the University of Lausanne Medical School identified Wisper (Wisp2 super-enhancer-associated RNA) as a cardiac fibroblast-enriched lncRNA that regulates cardiac fibrosis after injury. Wisper expression was ...

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