News

Target lncRNA gene for esophageal squamous-cell cancer found

lncRNA

Korean researchers said they have found a new gene that controls the development of esophageal squamous cell carcinoma (ESCC), intractable cancer in the esophagus. The finding is likely to allow researchers to develop a diagnostic platform and a treatment agent for esophagus cancer. The research team, led by Professor Lee Sang-kil at Yonsei Institute of Gastroenterology at Yonsei University College ...

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Long non-coding RNA implicated in triple negative breast cancer

lncRNA

A slice of RNA that doesn’t code for a protein manages to stifle tumor-suppressing genes and wreck the cellular mechanism that flags cancer cells for destruction by the immune system. Writing this month in Nature Immunology, a team led by scientists at MD Anderson shows that the long, non-coding RNA (lncRNA) called LINK-A is a potential therapeutic target for triple negative breast ...

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Abivax Treats First Patient in Phase 2a Rheumatoid Arthritis Clinical Trial of ABX464

lncRNA

Abivax, a clinical-stage biotechnology company harnessing the immune system to develop novel treatments for inflammatory diseases, viral diseases and cancer, announced today that the first patient was dosed in study ABX464-301, a phase 2a clinical trial of ABX464 to treat patients with moderate to severe active rheumatoid arthritis (RA). The trial has been fully approved in four countries (France, Poland, ...

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UVA Discovers lncRNA that regulates gene controlling growth of prostate cancer

lncRNA

Researchers have discovered a long non-coding RNA which could be used as a biomarker and in new therapies for prostate cancer. Cancer researchers at the School of Medicine have identified a key to controlling the growth and progression of prostate cancer, the second most common cancer in men. The researchers have dubbed this key “HULLK,” and they believe it could be used ...

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Scientists pinpoint new lncRNA mechanism that impacts HIV infection

lncRNA

A team of scientists led by Texas Biomed’s Assistant Professor Smita Kulkarni, Ph.D.  and Mary Carrington, Ph.D., at the Frederick National Laboratory for Cancer Research, published results of a study that pinpointed a long noncoding RNA molecule which influences a key receptor involved in HIV infection and progression of the disease. This newly-identified mechanism could open up a new avenue for control of ...

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Perfect Timing – Making the ‘Switch’ from Juvenile to Adult

lncRNA

Very little is known about how the onset of puberty is controlled in humans, but the discovery of a new gene in the roundworm C. elegans could be the “missing link” that determines when it’s time to make this juvenile-to-adult transition. Two genes, LIN28and MKRN3, are known to be associated with precocious puberty in humans, where juveniles as young as six may start developing ...

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