Long Noncoding RNAs: Past, Present, and Future

lncRNA Function

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been implicated in a range of developmental processes and diseases, but knowledge of the mechanisms by which they act is still surprisingly limited, and claims that almost the entirety of the mammalian genome is ...

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Long non-coding RNAs act like enhancers of gene regulation

from The Max Planck Institute for Molecular Medicine The regulation of gene activity belongs to the most challenging questions of modern biology. So far, scientists know only a few mechanisms to switch single genes on or off. Now, an international team of scientists from the US, Germany, and Spain has described a new mode to regulate gene activity. In the ...

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'Activating' RNA takes DNA on a loop through time and space

Activating RNAs

from PhysOrg Long segments of RNA—encoded in our DNA but not translated into protein—are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some ...

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Noncoding RNAs Offer Huge Therapeutic and Diagnostic Potential

FOR IMMEDIATE RELEASE PRESS RELEASE FROM MARY ANN LIEBERT, INC., PUBLISHERS Contact: Vicki Cohn Mary Ann Liebert, Inc., publishers (914) 740-2100 Noncoding RNAs Offer Huge Therapeutic and Diagnostic Potential New Rochelle, NY, February 14, 2013—As scientists continue to unravel the complexity of the human genome and to uncover vital elements that play a role in both normal physiology and ...

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RNA promotes metastasis in lung cancer


The vast majority – approximately 80 percent – of our DNA does not code for proteins, yet it gets transcribed into RNA. These RNA molecules are called non-coding and fulfill multiple tasks in the cell. Alongside a well-studied group of small RNAs, there is also a class of so-called long non-coding RNAs consisting of more than 200 nucleotides. Long non-coding ...

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Paired genes in stem cells shed new light on gene organization and regulation

gene pairs

CAMBRIDGE, Mass. (February 4, 2013) – Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding long noncoding RNAs (lncRNAs). Moreover, the mRNAs and lncRNAs are transcribed coordinately as stem cells differentiate into other cell types. This surprising ...

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