Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, the authors briefly: Introduce these three classes of long non-coding RNAs. Discuss their applications as ...
Read More »Parts of genome without a known function may play a key role in the birth of new proteins
The study analysed experiments carried out on six different species and identified almost 2,500 IncRNAs that were not in the databases Researchers in Biomedical Informatics at IMIM (Hospital del Mar Medical Research Institute) and at the Universitat Politècnica de Catalunya (UPC) have recently published a study in eLife showing that RNA called non-coding (IncRNA) plays an important role in the ...
Read More »Targeted Neuroblastoma Therapy One Step Closer
from ScienceNetwork WA by Anika Rodgers AUSTRALIAN researchers have uncovered new targets for therapy in the childhood cancer neuroblastoma. Histone Modification Group and Children’s Cancer Institute Australia for Medical Research’s Tao Liu says the researchers have been studying neuroblastoma in the hope of developing novel treatments. “Neuroblastoma is the most common solid tumour in early childhood and it accounts for ...
Read More »Newly Discovered Large Molecule Could be Key to Treating Heart Failure
from Bioresearch Online by C. Rajan, contributing writer Researchers at the Indiana University School of Medicine have just discovered a molecule which allows the heart to block a protein that creates genetic disruptions when the heart is subjected to stressful conditions, such as high blood pressure. This previously unknown molecule could help in treating and preventing heart failure. The newly ...
Read More »lncRNA Market Trends – Learn the latest about the expanding and evolving long noncoding RNA space.
from Genetic Engineering News by Enal Razvi, Ph.D. The focus of this GEN Market & Tech Analysis report is to present some of our recent industry tracking of the long noncoding RNA (lncRNA) space, as this space is expanding and evolving.Highlights of this report: The lncRNA space is expanding and the numbers of lncRNA sequences deposited in the biological databases ...
Read More »Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs
The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...
Read More »Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs
The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...
Read More »The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis
Thousands of long noncoding RNAs (lncRNAs) have been reported in mammalian genomes. These RNAs represent an important subset of pervasive genes involved in a broad range of biological functions. Aberrant expression of lncRNAs is associated with many types of cancers. Here, in order to explore the potential lncRNAs involved in hepatocellular carcinoma (HCC) oncogenesis, researchers at Jilin University, China performed ...
Read More »The Long Noncoding RNA Expression Profile of Hepatocellular Carcinoma Identified by Microarray Analysis
Thousands of long noncoding RNAs (lncRNAs) have been reported in mammalian genomes. These RNAs represent an important subset of pervasive genes involved in a broad range of biological functions. Aberrant expression of lncRNAs is associated with many types of cancers. Here, in order to explore the potential lncRNAs involved in hepatocellular carcinoma (HCC) oncogenesis, researchers at Jilin University, China performed ...
Read More »lnCeDB: Database of Human Long Noncoding RNA Acting as Competing Endogenous RNA
Long noncoding RNA (lncRNA) influences post-transcriptional regulation by interfering with the microRNA (miRNA) pathways, acting as competing endogenous RNA (ceRNA). These lncRNAs have miRNA responsive elements (MRE) in them, and control endogenous miRNAs available for binding with their target mRNAs, thus reducing the repression of these mRNAs. lnCeDB provides a database of human lncRNAs (from GENCODE 19 version) that can ...
Read More »