Clinical

Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer

lncRNA

Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, researchers from the Chinese Academy of Sciences and Fudan University analyzed lncRNA expression profiles of 493 ...

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A blood test for multiple sclerosis? Expect one in late May

lncRNA

MedCityNews – The medical toolbox for treating multiple sclerosis (MS) has progressed in leaps and bounds over the last two decades, as highlighted by the recent approval of Ocrevus for the most severe and treatment-resistant form of the disease. Despite this success, the underlying disease mechanisms and triggers are not well understood. This makes diagnosis a challenge — with very high ...

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Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma

lncRNA

Increasing evidence suggests that long non-coding RNAs (lncRNAs) may play a crucial role in many biological processes in a variety of cancers and serve as the basis for many clinical applications including prognostic biomarkers and potential therapeutic targets. Researchers from the Fudan University Shanghai Cancer Center set out to develop a prognostic lncRNA signature with RNA-seq data in lung adenocarcinomas. ...

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Three-lncRNA signature – a novel biomarker for the accurate prognosis prediction HNSCC

lncRNA

Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial ...

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lncRNA prostate cancer associated transcript-14 (PCAT-14) is prognostic for metastatic disease and survival

lncRNA

Long noncoding RNAs (lncRNAs) are an emerging class of relatively underexplored oncogenic molecules with biological and clinical significance. Current inadequacies for stratifying patients with aggressive disease presents a strong rationale to systematically identify lncRNAs as clinical predictors in localized prostate cancer. To identify RNA biomarkers associated with aggressive prostate cancer researchers from the Washington University School of Medicine obtained radical ...

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lncRNAs – novel candidate biomarkers to identify breast cancer patients at high risk of tumor recurrence

lncRNA

Deregulation of long non-coding RNAs (lncRNAs) expression has been proven to be involved in the development and progression of cancer. However, expression pattern and prognostic value of lncRNAs in breast cancer recurrence remain unclear. Here, researchers from Harbin Medical University analyzed lncRNA expression profiles of breast cancer patients who did or did not develop recurrence by repurposing existing microarray datasets from ...

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OSBREAC research yields a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal-like subtype associates with increased EGFR signaling, while another, the HER2-enriched subtype, engages a kin of EGFR Based on the premise that EGFR-regulated lncRNAs might control the aggressiveness of basal-like ...

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Panel of five lncRNAs provides a signature for the diagnosis and prognosis of gastric cancer

lncRNA

Gastric cancer (GC) is one of the most aggressive malignancies and has a poor prognosis. Identifying novel diagnostic and prognostic markers is of great importance for the management and treatment of GC. Long non-coding RNAs (lncRNAs), which are involved in multiple processes during the development and progression of cancer, may act as potential biomarkers of GC. Here, by performing data ...

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