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lncRNA SNHG6 is a Potential Biomarker for Hepatocellular Carcinoma

lncRNA

Long Non-coding RNAs (lncRNAs) refer to all non-protein coding transcripts longer than 200 nucleotides. Their critical roles in different biological pathways have been already well established. Altered expression of lncRNAs can be involved in the cancer initiation and/or progression. Since patients with hepatocellular carcinoma (HCC) are usually diagnosed in late stages, developing diagnostic methods seems to be essential. In this ...

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A Pipeline for Discovery of DNA methylation patterns in long non-coding RNAs

lncRNA

A systematic pipeline is proposed to discover methylation patterns for lncRNAs. Subtype specific and common lncRNAs differ greatly in functions and structures. Methylation modules enhances the accuracy of prediction of cancers. Despite growing evidence demonstrates that the long non-coding ribonucleic acids (lncRNAs) are critical modulators for cancers, the knowledge about the DNA methylation patterns of lncRNAs is quite limited. Researchers ...

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A blood test for multiple sclerosis? Expect one in late May

lncRNA

MedCityNews – The medical toolbox for treating multiple sclerosis (MS) has progressed in leaps and bounds over the last two decades, as highlighted by the recent approval of Ocrevus for the most severe and treatment-resistant form of the disease. Despite this success, the underlying disease mechanisms and triggers are not well understood. This makes diagnosis a challenge — with very high ...

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The novel long intergenic noncoding RNA UCC promotes colorectal cancer

lncRNA

The human genome contains thousands of long intergenic noncoding RNAs (lincRNAs). However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in colorectal cancer (CRC) remain elusive. Researchers at Sun Yat-sen University found a novel lincRNA termed upregulated in CRC (UCC) was highly expressed in human CRC tissues and cell lines. UCC levels correlated with lymph node ...

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Could long non-coding RNAs be used as biomarkers for urothelial carcinoma?

exosomes

Bioanalysis Zone – Amy Craddock, Future Science Group – Collaborative research from medical faculties across Germany and Hungary has investigated the potential use of long non-coding RNAs as diagnostic and prognostic biomarkers for urothelial carcinoma. In previous studies, it has been identified that a number of long non-coding RNAs are overexpressed in urothelial carcinoma; as a result it has been ...

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Protein sequestration as a normal function of long noncoding RNAs

lncrna

An emerging class of long noncoding RNAs (lncRNAs) function as decoy molecules that bind and sequester proteins thereby inhibiting their normal functions. Titration of proteins by lncRNAs has wide-ranging effects affecting nearly all steps in gene expression. While decoy lncRNAs play a role in normal physiology, RNAs expressed from alleles containing nucleotide repeat expansions can be pathogenic due to protein ...

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The first molecular beacons-based imaging of intracellular dynamics and localization of single long noncoding RNAs

lncRNA

Analysis of RNA dynamics and localization at the single-molecule level in living cells has been predominantly achieved by engineering target RNAs with large insertions of tandem repeat sequences that are bound by protein-based or oligonucleotide-based fluorescent probes. Thus, individual RNAs are tagged by multiple fluorescent probes, making them detectable by fluorescence microscopy. Since large insertions may affect RNA processes including ...

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LINC00152 – A pivotal oncogenic long non-coding RNA in human cancers

lncRNA

In recent years, increasing evidence has shown the potential role of long non-coding RNAs (lncRNAs) in multiple cancers. Deregulation of lncRNAs was detected being closely associated with many kinds of tumours where they can act as a tumour suppressor or accelerator. LINC00152 was identified as an oncogene involved in many kinds of cancers, such as gastric cancer, hepatocellular carcinoma, colon ...

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Insights into the Function of Long Noncoding RNAs in Sepsis Revealed by Gene Co-Expression Network Analysis

lncRNA

Sepsis is a major cause of death and its incidence and mortality increase exponentially with age. Most gene expression studies in sepsis have focused in protein-coding genes and the expression patterns, and potential roles of long noncoding RNAs (lncRNAs) have not been investigated yet. Here, researchers from the Universidade de São Paulo performed co-expression network analysis of protein-coding and lncRNAs measured ...

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The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules

lncRNA

Molecular mechanisms by which long noncoding RNA (lncRNA) molecules may influence cancerous condition are poorly understood. The aberrant expression of SPRIGHTLY lncRNA, encoded within the drosophila gene homolog Sprouty-4 intron, is correlated with a variety of cancers, including human melanomas. A team led by researchers at the Sanford Burnham Prebys Medical Discovery Institute demonstrate by SHAPE-seq and dChIRP that SPRIGHTLY ...

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