Blog

Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells

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Of the thousands of long noncoding RNAs expressed in embryonic stem cells (ESCs), few have known roles and fewer have been functionally implicated in the regulation of self-renewal and pluripotency, or the reprogramming of somatic cells to the pluripotent state. In ESCs, Cyrano is a stably expressed long intergenic noncoding RNA with no previously assigned role. Researchers from the University ...

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lncRNA-screen – an interactive platform for computationally screening long non-coding RNAs in large genomics datasets

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Long non-coding RNAs (lncRNAs) have emerged as a class of factors that are important for regulating development and cancer. Computational prediction of lncRNAs from ultra-deep RNA sequencing has been successful in identifying candidate lncRNAs. However, the complexity of handling and integrating different types of genomics data poses significant challenges to experimental laboratories that lack extensive genomics expertise. To address this ...

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Linc-ing the Noncoding Genome to Heart Function

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Cardiovascular disease is a major health concern worldwide. Hypertensive stress, inflammation or injury of heart muscle, and abnormal rhythms due to valve dysfunction can contribute to the enlargement of cardiac cells known as ‘pathological’ hypertrophy. Pathological hypertrophy can further lead to fibrosis or scarring of tissue, reduced capillary densities, increased levels of proinflammatory cytokines, dysregulation of signaling pathways, autophagy, and ...

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Panel of seven long noncoding RNA as a candidate prognostic biomarker for ovarian cancer

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Ovarian cancer is one of the most common and lethal gynecological malignancies. The diagnosis of ovarian cancer is often at an advanced stage. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) play important roles during ovarian tumorigenesis. In this study, using the lncRNA-mining approach, researchers from the Chinese Academy of Sciences and Fudan University analyzed lncRNA expression profiles of 493 ...

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Global ID of lncRNAs associated with insecticide resistance in diamondback moths

Long noncoding RNAs (lncRNAs) are now considered important regulatory factors, with a variety of biological functions in many species including insects. Some lncRNAs have the ability to show rapid responses to diverse stimuli or stress factors and are involved in responses to insecticide. However, there are no reports to date on the characterization of lncRNAs associated with chlorantraniliprole resistance in ...

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Researchers identify cancer-related long noncoding RNAs in quintuple-negative lung adenocarcinoma

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Lung adenocarcinoma (LUAD) is a common subtype of non-small cell lung cancer prevalent in Asia. There is a dearth of understanding regarding the transcriptome landscape of LUAD without primary known driver mutations. In this study, researchers at MSD China R&D used LUAD samples without well-known driver mutations occurring in EGFR, KRAS, ALK, ROS1 or RET (quintuple-negative) for transcriptome study with ...

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The prognostic value of long noncoding RNAs in prostate cancer

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The abnormally expressed LncRNAs played irreplaceable roles in the prognosis of prostate cancer (PCa). Therefore, researchers from Wuhan University conducted this systematic review and meta-analysis to summarize the association between the expression of LncRNAs, prognosis and clinicopathology of PCa. 18 eligible studies were recruited into their analysis, including 18 on prognosis and 9 on clinicopathological features. Results indicated that aberrant ...

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Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy

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Long non-coding RNAs (lncRNAs) are defined as a class of RNA transcripts longer than 200 nucleotides encoded by mammalian genomes that lack protein-coding potential. LncRNA ASBEL has been identified as an anti-sense transcript of BTG3 (B cell translocation gene 3) gene, which encodes an anti-proliferation protein. Remarkable down-regulation of BTG3 has been reported in triple-negative breast cancer (TNBC). In the ...

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A Review of Recent Computational Methods for Predicting Noncoding RNAs

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Noncoding RNAs (ncRNAs) play important roles in various cellular activities and diseases. Researchers from Hebei University of Science and Technology, present a comprehensive review on computational methods for ncRNA prediction, which are generally grouped into four categories: (1) homology-based methods, that is, comparative methods involving evolutionarily conserved RNA sequences and structures, (2) de novo methods using RNA sequence and structure features, ...

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Post-doc Position Available – lncRNAs in Hematopoiesis and Leukemia

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One (1) position for a post-doctoral fellow or graduate student is available to identify and characterize Gfi1 and/or Gfi1b regulated long noncoding RNAs (lncRNAs), to determine the regulation patterns of the lncRNA genes by Gfi1 or Gfi1b and to investigate the biological functions of Gfi1 controlled lncRNAs in lymphoid and myeloid differentiation and in the development of leukemia and lymphoma ...

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