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Post-doc position available – microRNA/lncRNA-influenza virus interactions

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Job Description: Postdoctoral Fellow position is available in the Oklahoma Center for Respiratory and Infectious Diseases and the Interdisciplinary Program in Regenerative Medicine at Oklahoma State University to study microRNA/LncRNA-influenza virus interactions, and/or engineering stem cells with non-coding RNAs for treating lung diseases. Responsible, dedicated, self-motivated and hard-working candidates are encouraged to apply. A background in lung diseases, influenza virus ...

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EVLncRNAs – the current largest database for experimentally validated lncRNAs

Long non-coding RNAs (lncRNAs) play important functional roles in various biological processes. Early databases were utilized to deposit all lncRNA candidates produced by high-throughput experimental and/or computational techniques to facilitate classification, assessment and validation. As more lncRNAs are validated by low-throughput experiments, several databases were established for experimentally validated lncRNAs. However, these databases are small in scale (with a few ...

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Prognostic and biologic significance of long noncoding RNA profiling in leukemia

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Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein, researchers from the Ohio State University Comprehensive Cancer Center investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of younger adults (aged <60 years) with de ...

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The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence

Long noncoding RNAs (lncRNAs) have emerged as potent regulators of breast cancer development and progression, including the metastatic spread of disease. Through in silico and biological analyses, investigators at Case Western Reserve University identified a novel lncRNA, BMP/OP-Responsive Gene (BORG), whose expression directly correlates with aggressive breast cancer phenotypes, as well as with metastatic competence and disease recurrence in multiple clinical cohorts. ...

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Post-doc Position Available – Digestive Diseases

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David Geffen School Of Medicine – Medicine-Gastroenterology Recruitment Period – Open August 17th, 2017 through November 17th, 2017 Description The Padua lab has a keen interest in understanding gene regulation and signaling pathways in the context of complex biological phenomena. Our clinical interests are in inflammatory bowel disease (IBD) and colon cancer diagnosis. One focus of the lab will be ...

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Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma

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Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives for recurrent LUSC due to the lack of specific driver molecules. To investigate the prospective role of lncRNAs in the tumorigenesis and progression of LUSC, researchers at Guangxi Medical University calculated aberrantly expressed lncRNAs based on The Cancer Genome Atlas ...

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Identification of Novel Long Non-coding and Circular RNAs in Human Papillomavirus-Mediated Cervical Cancer

Cervical cancer is the third most common cancer worldwide and the fourth leading cause of cancer-associated mortality in women. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) may play key roles in the carcinogenesis of different cancers; however, little is known about the mechanisms of lncRNAs and circRNAs in the progression and metastasis of cervical cancer. ...

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A stronger perturbation of lncRNAs expression may lead to the dysfunction of mitochondria in Down syndrome

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Trisomy 21 is the most common chromosomal disorder and underlies Down syndrome. Epigenetics, such as DNA methylation and post-translational histone modifications, plays a vital role in Down syndrome. However, the functions of epigenetics-related long noncoding RNAs (lncRNAs), found to have an impact on neural diseases such as Alzheimer’s disease, remain unknown in Down syndrome. In this study, researchers from Shanghai ...

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Genomic recycling: Ancestral genes take on new roles

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One often hears about the multitude of genes we have in common with chimps, birds or other living creatures, but such comparisons are sometimes misleading. The shared percentage usually refers only to genes that encode instructions for making proteins – while overlooking regulatory genes, which nonetheless make up a large part of the genome. “Humans and fish, for instance, share ...

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How do lncRNAs regulate transcription?

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It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. ...

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