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A new approach to RNA sequencing reveals thousands of previously inaccessible lncRNA fragments in blood plasma

lncrna

New method opens unexplored realms for liquid biopsies A new approach to RNA sequencing reveals thousands of previously inaccessible RNA fragments in blood plasma that might serve as disease- and organ-specific biomarkers Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are ...

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LDAIR, a lncRNA regulates seasonal changes in stress response

exosomes

Biologists at the National Institute for Basic Biology and the Institute of Transformative Bio-Molecules (ITbM) at Nagoya University have discovered that long non-coding RNA regulates seasonal changes in stress response in medaka fish. The results of this study were reported in Nature Ecology & Evolution. In temperate zones, the environment fluctuates greatly depending on the season, and animals living in these ...

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Scientists link lncRNA leptin with obesity

lncrna

Obesity is a major public-health problem in the United States and around the world, with an estimated 650 million people suffering from the condition. One of the biggest challenges of this ever-worsening condition is figuring out why people become obese in the first place, and why some people are more vulnerable to obesity than others. Now, scientists at The Rockefeller ...

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Measures of co-expression for improved function prediction of long non-coding RNAs

lncrna

Almost 16,000 human long non-coding RNA (lncRNA) genes have been identified in the GENCODE project. However, the function of most of them remains to be discovered. The function of lncRNAs and other novel genes can be predicted by identifying significantly enriched annotation terms in already annotated genes that are co-expressed with the lncRNAs. However, such approaches are sensitive to the ...

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