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Identification of lncRNAs and molecular subtyping of pancreatic ductal adenocarcinoma

lncrna

Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. Researchers at the Columbia University Medical Center developed ...

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Newly discovered lncRNA gene may protect against heart disease

lncRNA

UCLA-led study finds that so-called ‘selfish’ gene acts to remove cholesterol from blood vessels Scientists have identified a gene that may play a protective role in preventing heart disease. Their research revealed that the gene, called MeXis, acts within key cells inside clogged arteries to help remove excess cholesterol from blood vessels. Published in the journal Nature Medicine, the UCLA-led study ...

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An epigenomic approach to identifying differential overlapping and cis-acting lncRNAs

lncrna

Long noncoding RNAs (lncRNAs) are critical regulators of cell biology whose alteration can lead to the development of diseases such as cancer. The potential role of lncRNAs and their epigenetic regulation in response to platinum treatment are largely unknown. Researchers at La Paz University Hospital analyzed four paired cisplatin-sensitive/resistant non-small cell lung cancer and ovarian cancer cell lines. The epigenetic landscape ...

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Tobacco-Related Disease Research Program to fund studies on lncRNA

lncRNA

The California Tobacco-Related Disease Research Program has awarded $1.8 million in grants and fellowships to UCSC biomedical researchers Biomedical researchers at UC Santa Cruz have won major funding to investigate lung cancer and chronic obstructive pulmonary disease (COPD) from the California Tobacco-Related Disease Research Program, which is supported by the state tax on cigarettes. The awards include a $550,000 grant ...

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Identification of novel lncRNA PANDAR-protein interaction partners involved in splicing regulation

lncrna

Interactions of long non-coding RNAs (lncRNA) with proteins play important roles in the regulation of many cellular processes. PANDAR (Promotor of CDKN1A Antisense DNA damage Activated RNA) is a lncRNA that is transcribed in a p53-dependent manner from the CDKN1A promoter and is involved in the regulation of proliferation and senescence. Overexpression of PANDAR has been observed in several tumor ...

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Long noncoding RNA complementarity and target transcripts abundance

lncRNA

Eukaryotic mRNA metabolism regulates its stability, localization, and translation using complementarity with counter-part RNAs. To modulate their stability, small and long noncoding RNAs can establish complementarity with their target mRNAs. Although complementarity of small interfering RNAs and microRNAs with target mRNAs has been studied thoroughly, partial complementarity of long noncoding RNAs (lncRNAs) with their target mRNAs has not been investigated ...

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