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New lncRNA biomarkers for neuroblastoma

lncRNA

Two new biomarkers for a type of cancer in children called neuroblastoma have been identified in a study published in the journal Cancer Cell. The findings are expected to have immediate significance for disease prognosis, and eventually also for treatment. “There is a need for new methods of treatment for high-risk patients, and that’s where our research can lead to ...

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Termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

lncrna

Most DNA in the genomes of higher organisms does not code for proteins. RNA Polymerase II (Pol II) transcribes non-coding DNA into long non-coding RNAs (lncRNAs), but biological roles of lncRNA are unclear. Researchers at the University of Copenhagen found that mutations in the yeast lncRNA CUT60 result in poor growth. Defective termination of CUT60 transcription causes read-through transcription across the ...

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A long noncoding RNA-associated competing endogenous RNA network in periodontitis

lncrna

Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. University of Leipzig researchers constructed a lncRNA-associated ceRNA network from miRNA and mRNA expression ...

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