Monthly Archives: February 2018

Unravelling the long non-coding RNA profile of undifferentiated large cell lung carcinoma

lncrna

Undifferentiated large cell lung carcinoma (LCLC) accounts for 2.9–9% of total lung cancers. Recently, RNA-seq based studies have revealed major genomic aberrations in LCLC. In this study, researchers from the Indian Institute of Technology aim to identify long non-coding RNAs (LncRNAs) expression pattern specific to LCLC. The RNA-seq profile of LCLC and other non-small cell lung carcinoma (NSCLC) was downloaded ...

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Post-doc Position Available – Fibrosis and long noncoding RNAs

lncrna

A postdoctoral position is available for a highly-motivated candidate to study mechanisms of hepatic stellate cell biology and liver fibrosis in the Mullen Laboratory in the Gastrointestinal Unit at Massachusetts General Hospital and Harvard Medical School. The candidate will lead projects to understand how long noncoding RNAs and protein-coding genes regulate hepatic stellate activity and liver fibrosis using both tissue culture and mouse models. ...

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Splicing regulation by long noncoding RNAs

lncRNA

Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs ...

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Long non-coding RNAs in ischemic stroke

lncRNA

Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using ...

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Characterization of the lncRNA transcriptome in mESC-derived motor neurons

lncRNA

Long non-coding RNAs (lncRNAs) are currently recognized as crucial players in nervous system development, function and pathology. In Amyotrophic Lateral Sclerosis (ALS), identification of causative mutations in FUS and TDP-43 or hexanucleotide repeat expansion in C9ORF72 point to the essential role of aberrant RNA metabolism in neurodegeneration. In this study, by taking advantage of an in vitro differentiation system generating ...

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Identification of lncRNAs and molecular subtyping of pancreatic ductal adenocarcinoma

lncrna

Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. Researchers at the Columbia University Medical Center developed ...

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Newly discovered lncRNA gene may protect against heart disease

lncRNA

UCLA-led study finds that so-called ‘selfish’ gene acts to remove cholesterol from blood vessels Scientists have identified a gene that may play a protective role in preventing heart disease. Their research revealed that the gene, called MeXis, acts within key cells inside clogged arteries to help remove excess cholesterol from blood vessels. Published in the journal Nature Medicine, the UCLA-led study ...

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