Monthly Archives: December 2017

Researchers use CRISPR to show that the short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation

lncRNA

Alternative splicing of mRNA precursors results in multiple protein variants from a single gene and is critical for diverse cellular processes and development. Xist encodes a long noncoding RNA which is a central player to induce X-chromosome inactivation in female mammals and has two major splicing variants: long and short isoforms of Xist RNA. Although a differentiation-specific and a female-specific ...

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Long Noncoding RNA in Cancer

lncrna

Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the human genome, may hold missing drivers of cancer and have gained attention recently as a potentially crucial...

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Profiling long noncoding RNA of multi-tissue transcriptome enhances porcine noncoding genome annotation

lncRNA

To construct a comprehensive pig noncoding transcriptome and further enhance porcine noncoding genome annotation, researchers at China Agricultural University performed tissue-based long noncoding RNA (lncRNA) profiling. They identified 32,212 nonredundant lncRNA isoforms corresponding to 18,676 lncRNA loci across 34 normal pig tissues using high-throughput sequencing. Furthermore, they globally assessed the potential relationship between these identified lncRNAs and known protein-coding genes ...

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Genome-wide identification of long non-coding RNA genes and their association with insecticide resistance

lncRNA

Long non-coding RNA (lncRNA) is a class of noncoding RNA >200 bp in length that has essential roles in regulating a variety of biological processes. Here, researchers from Yichun University constructed a computational pipeline to identify lncRNA genes in the diamondback moth (Plutella xylostella), a major insect pest of cruciferous vegetables. In total, 3,324 lncRNAs corresponding to 2,475 loci were identified ...

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How Defeating THOR Could Bring a Hammer Down on Cancer

Researchers have identified and characterized a new type of RNA protein called THOR that plays a role in cancer development — and could serve as a target for drug development. It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer, too. Researchers at the University of Michigan Comprehensive Cancer ...

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A deep learning method for lincRNA detection using auto-encoder algorithm

lncRNA

RNA sequencing technique (RNA-seq) enables scientists to develop novel data-driven methods for discovering more unidentified lincRNAs. Meantime, knowledge-based technologies are experiencing a potential revolution ignited by the new deep learning methods. By scanning the newly found data set from RNA-seq, scientists have found that: (1) the expression of lincRNAs appears to be regulated, that is, the relevance exists along the ...

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RNA-seq-based genome annotation and identification of long-noncoding RNAs in the winegrape Riesling

lncRNA

The technological advances of RNA-seq and de novo transcriptome assembly have enabled genome annotation and transcriptome profiling in highly heterozygous species such as grapevine (Vitis vinifera L.). This work is an attempt to utilize a de novo-assembled transcriptome of the V. vinifera cultivar ‘Riesling’ to improve annotation of the grapevine reference genome sequence. Here researchers from Missouri State University and the ...

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