Monthly Archives: November 2017

Post-doc position available – bioinformatics of long noncoding RNAs

lncrna

The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases. We are particularly interested in studying RNA-DNA interactions as mechanisms of transcriptional control. For example, we have recently shown how the long-noncoding RNA HOTAIR interacts with DNA via triple helices to control ...

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A computational approach to predict scaffolding lncRNAs at large scale

lncRNA

The human transcriptome contains thousands of long non-coding RNAs (lncRNAs). Characterizing their function is a current challenge. An emerging concept is that lncRNAs serve as protein scaffolds, forming ribonucleoproteins and bringing proteins in proximity. However, only few scaffolding lncRNAs have been characterized and the prevalence of this function is unknown. Here, researchers from the Aix-Marseille University, Inserm propose the first computational ...

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The Long and Short of It – Long Non-Coding RNAs

lncRNA

from Biocompare by Gina Shaw – Human and other mammalian genomes pervasively transcribe tens of thousands of long non-coding RNAs (lncRNAs). The latest edition of data produced by the public research consortium GenCode (version #27) catalogs just under 16,000 lncRNAs in the human genome, producing nearly 28,000 transcripts; when other databases are included, more than 40,000 lncRNAs are known. These ...

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NONCODEV5 – a comprehensive annotation database for long non-coding RNAs

lncRNA

NONCODE is a systematic database that is dedicated to presenting the most complete collection and annotation of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs). Since NONCODE 2016 was released two years ago, the amount of novel identified ncRNAs has been enlarged by the reduced cost of next-generation sequencing, which has produced an explosion of newly identified data. The third-generation ...

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University of Newcastle lands $675K to study lncRNA

lncRNA

In total, the University of Newcastle (UON) has attracted $12.2m in the latest round of National Health and Medical Research Council (NHMRC) funding to investigate some of the nation’s and world’s greatest health challenges. Senior Deputy Vice-Chancellor (Research and Innovation), Professor Kevin Hall, said the NHMRC’s support for Newcastle’s researchers was testament to the University’s reputation for conducting world-class research. ...

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Circulating lncRNAs Serve as Diagnostic Markers for Hepatocellular Carcinoma

lncRNA

Circulating (serous or plasmic) long non-coding RNA (lncRNA) as biomarkers for predicting the diagnosis or prognosis of human disease have been well documented. Due to the sensibility or specificity limitation of Alpha Fetoprotein (AFP), a cluster lncRNAs were revealed as fingerprints for hepatocellular carcinoma (HCC). In this study, researchers at Huai’an First People’s Hospital enrolled all the reported circulating lncRNAs ...

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A new lncRNA in adenocarcinoma is associated with overall survival

lncRNA

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. Researchers from the University of ...

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