Monthly Archives: October 2017

Fusing multiple protein-protein similarity networks can effectively boost the performance of predicting lncRNA-protein interactions

lncrna

Long non-coding RNA (lncRNA) plays important roles in many biological and pathological processes, including transcriptional regulation and gene regulation. As lncRNA interacts with multiple proteins, predicting lncRNA-protein interactions (lncRPIs) is an important way to study the functions of lncRNA. Up to now, there have been a few works that exploit protein-protein interactions (PPIs) to help the prediction of new lncRPIs. ...

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Featured lncRNA Job – Biomedical Scientist

lncRNA

Date Posted 08/14/2017 Open Until Filled No Anticipated Application Deadline (Close date) 10/29/2017 Working Title Biomedical Scientist Job Classification Research Scientist Department Name 33203-Pharm-Pharmaceutical Science Job Type Research Associate Position Number 0135404 Hiring Range TBD based on qualifications Position Description Dr. Da Yang’s laboratory at the University of Pittsburgh is seeking a highly motivated and organized Biomedical Scientist to join ...

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lncRNA HANR promotes tumorigenesis and increase of chemoresistance

lncRNA

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated for a variety of cancers, including hepatocellular carcinoma. However, the effect and mechanism of lncRNAs in HCC tumorigenesis and chemoresistance have not been extensively characterized. In the current study, ...

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lncRNASNP2 – an updated database of functional SNPs and mutations in human and mouse lncRNAs

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, the developers at Huazhong University of Science and Technology updated their lncRNASNP to version 2. lncRNASNP2 provides comprehensive information of SNPs and mutations in lncRNAs, as well as their impacts on lncRNA structure and function. ...

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Elucidating the role of host long non-coding RNA during viral infection

lncrna

Research over the past decade has clearly shown that long non-coding RNAs (lncRNAs) are functional. Many lncRNAs can be related to immunity and the host response to viral infection, but their specific functions remain largely elusive. The vast majority of lncRNAs are annotated with extremely limited knowledge and tend to be expressed at low levels, making ad hoc experimentation difficult. ...

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The diagnostic/prognostic potential and molecular functions of long non-coding RNAs in the exosomes

lncrna

Cholangiocarcinoma (CCA) is an aggressive malignancy associated with unfavorable prognosis, and it’s difficult to diagnose and no effective treatments are available. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and metastasis. Intact lncRNAs from exosomes have sparked much interest as potential biomarker for the non-invasive analysis of disease. Here, via exosome sequencing on lncRNAs, GO analysis, KEGG pathway and ...

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Lnc2Meth – a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease

lncrna

Lnc2Meth, an interactive resource to identify regulatory relationships between human long non-coding RNAs (lncRNAs) and DNA methylation, is not only a manually curated collection and annotation of experimentally supported lncRNAs-DNA methylation associations but also a platform that effectively integrates tools for calculating and identifying the differentially methylated lncRNAs and protein-coding genes (PCGs) in diverse human diseases. The resource provides: (i) ...

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EPLMI – large-scale lncRNA-miRNA interaction profiling

lncrna

The interaction of miRNA and lncRNA is known to be important for gene regulations. However, not many computational approaches have been developed to analyse known interactions and predict the unknown ones. Given that there are now more evidences that suggest that lncRNA-miRNA interactions are closely related to their relative expression levels in the form of a titration mechanism, researchers from ...

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Post-doc Position Available – Fibrosis and long non-coding RNAs

lncrna

A postdoctoral position is available for a highly-motivated candidate to study mechanisms of hepatic stellate cell biology and liver fibrosis in the Mullen Laboratory in the Gastrointestinal Unit at Massachusetts General Hospital and Harvard Medical School. The candidate will lead projects to understand how long noncoding RNAs and protein-coding genes regulate hepatic stellate activity and liver fibrosis using both tissue ...

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A Support Vector Machine based method to distinguish long non-coding RNAs from protein coding transcripts

lncRNA

In recent years, a rapidly increasing number of RNA transcripts has been generated by thousands of sequencing projects around the world, creating enormous volumes of transcript data to be analyzed. An important problem to be addressed when analyzing this data is distinguishing between long non-coding RNAs (lncRNAs) and protein coding transcripts (PCTs). Thus, we present a Support Vector Machine (SVM) ...

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