Monthly Archives: September 2017

BRWLDA – bi-random walks for predicting lncRNA-disease associations

lncrna

Increasing efforts have been done to figure out the association between lncRNAs and complex diseases. Many computational models construct various lncRNA similarity networks, disease similarity networks, along with known lncRNA-disease associations to infer novel associations. However, most of them neglect the structural difference between lncRNAs network and diseases network, hierarchical relationships between diseases and pattern of newly discovered associations. In ...

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A Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells

lncRNA

Cardiogenesis processes in human and animals have differential dynamics, suggesting the existence of species-specific regulators during heart development. However, it remains a challenge to discover the human-specific cardiac regulatory genes, given that most coding genes are conserved. Here, researchers at the University of Pittsburgh School of Medicine report the identification of a human-specific long noncoding RNA, Heart Brake LncRNA 1 ...

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The Future of Biomarkers and Genomics

lncrna

from UroToday.com by  Zachary Klaassen, – Professor Manfred Wirth from Germany provided an update on the future of biomarkers and genomics at this afternoon’s EAU Update in Prostate Cancer in Vienna, Austria. Dr. Wirth divided his presentation into three subsections: Why are biomarkers needed for prostate cancer? There are several reasons according to Dr. Wirth why biomarkers are needed for prostate cancer, ...

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Long noncoding RNAs – Potential regulators involved in the pathogenesis of polycystic ovary syndrome

lncrna

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, and its etiology remains poorly understood. Altered activities of long noncoding RNAs (lncRNAs) have been associated with human diseases and development. However, the roles of lncRNAs are unknown in reproductive medicine. Researchers from the Southern Medical University investigated the potential role of lncRNAs ...

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Epidermal long non-coding RNAs are regulated by ultraviolet irradiation

lncRNA

Ultraviolet (UV) radiation causes the harmful effects on skin by the photochemical reaction and gene expression regulation. Recent evidences have shown that long non-coding RNAs (lncRNAs) play critical roles in a diverse range of biological functions. However, research on the effects of UV irradiation on lncRNA expression in epidermal cells is limited. The aim of this study was to identify ...

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The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

The popularization of genome-wide analyses and RNA sequencing led to the discovery that a large part of the human genome, while effectively transcribed, does not encode proteins. Long non-coding RNAs have emerged as critical regulators of gene expression in both normal and disease states. Studies of long non-coding RNAs expressed in the heart, in combination with gene association studies, revealed ...

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Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis

lncRNA

Long noncoding RNAs (lncRNAs) are increasingly recognized as vital components of gene programs controlling cell differentiation and function. Central to their functions is an ability to act as scaffolds or as decoys that recruit or sequester effector proteins from their DNA, RNA, or protein targets. lncRNA-modulated effectors include regulators of transcription, chromatin organization, RNA processing, and translation, such that lncRNAs ...

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lnRNA discovery could help boost plant heat, drought tolerance

Texas A&M AgriLife Research scientists have discovered a ribonucleic acid, or RNA, that can increase the thale cress plant’s resistance to stress from drought and salt. The discovery could help illuminate a new pathway to engineering drought- and salt-tolerant plants, including food crops, said Dr. Liming Xiong, AgriLife Research associate professor, Dallas. The research is published in the journal Plant ...

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Discriminating cirRNAs from other lncRNAs using a hierarchical extreme learning machine (H-ELM) algorithm

lncRNA

As non-coding RNAs, circular RNAs (cirRNAs) and long non-coding RNAs (lncRNAs) have attracted an increasing amount of attention. They have been confirmed to participate in many biological processes, including playing roles in transcriptional regulation, regulating protein-coding genes, and binding to RNA-associated proteins. Until now, the differences between these two types of non-coding RNAs have not been fully uncovered. It is ...

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lncRNAs and immunity – watchdogs for host pathogen interactions

lncRNA

Immune responses combat various infectious agents by inducing inflammatory responses, antimicrobial pathways and adaptive immunity. The polygenic responses to these external stimuli are temporally and coordinately regulated. Specific lncRNAs are induced to modulate innate and adaptive immune responses which can function through various target interactions like RNA-DNA, RNA-RNA, and RNA-protein interaction and hence affect the immunogenic regulation at various stages ...

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