Monthly Archives: August 2017

Long noncoding RNAs coordinate functions between mitochondria and the nucleus

lncRNA

In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial-specific nucleic acids and proteins. To maintain homeostasis of the entire cell, an intense cross-talk between mitochondria and the nucleus, mediated by encoded noncoding RNAs (ncRNAs), as well as proteins, is required. Long ncRNAs (lncRNAs) contain characteristic structures, and they are involved ...

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Gene therapy using lncRNA could lower risk for heart disease

lncRNA

FINDINGS Scientists from UCLA and the Howard Hughes Medical Institute successfully used a gene that suppresses cholesterol levels as part of a treatment to reduce plaque in mice with a disorder called familial hypercholesterolemia. In a preclinical study, researchers found that the gene, LeXis, lowered cholesterol and blockages in the arteries, and the treatment appeared to reduce the build-up of ...

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Upcoming Symposium – The Non-Coding Genome

lncrna

EMBL Heidelberg, Germany 13 – 16 Sep 2017 Topics Non-coding RNAs in prokaryotes miRNAs: biogenesis, function and mechanisms siRNAs and piRNAs Transcriptional silencing and dosage compensation Gene silencing in plants Long non-coding RNAs Why attend? In the 50 years since RNA was identified as a central component in the flow of genetic information, it has become increasingly clear that RNA performs ...

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Long, mysterious strips of RNA contribute to low sperm count

lncRNA

Scientists at Case Western Reserve University School of Medicine have found distinctive portions of genetic material–known as lncRNAs–that help sperm develop. Male mice lacking a particular lncRNA have low sperm count, suggesting lncRNAs could represent novel infertility drug targets. “Infertility affects 10 to 15 percent of couples in the United States, with the vast majority of cases due to unknown ...

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Gene regulation in the immune system by long noncoding RNAs

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and adaptive cell types. Here, Stanford University researchers discuss mechanisms used by lncRNAs to regulate genes encoding products involved in the immune response, including direct ...

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MUSC researchers show how long non-coding RNA promotes tumor formation

A mechanism that pushes a certain gene to produce a non-coding form of RNA instead of its protein-coding alternative can promote the growth of cancer, report researchers at the Medical University of South Carolina (MUSC) in an article published online ahead of print on August 21, 2017 by Nature Cell Biology. The non-coding RNA soaks up a microRNA that prevents epithelial-to-mesenchymal ...

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Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer

lncRNA

Non‑coding RNAs serve important roles in regulating the expression of certain genes and are involved in the principal biological processes of breast cancer. The majority of studies have focused on defining the regulatory functions of long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs/miRs), and few studies have investigated how lncRNAs and miRNAs are transcriptionally regulated. In the present study, based on ...

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Post-doc position available to study novel lncRNAs

lncRNA

A post-doctoral position is available immediately to study novel lncRNAs in a well-funded laboratory at the University of Rochester School of Medicine and Dentistry.  The laboratory was the first to report on a human-specific lncRNA (SENCR) enriched in vascular cells and has been a leading cardiovascular lab in CRISPR genome editing.  The lab uses a broad palette of tools to ...

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New Reference Text Published – Long Non Coding RNA Biology

lncRNA

In recent years, our functional understanding of the genome has changed dramatically. The discovery of pervasive transcription and the prevalence of noncoding RNAs (ncRNAs) have challenged the traditional definition of genes and what should be considered a functional region of the genome. Noncoding RNAs are defined as transcripts that do not encode proteins. Formally, this classification includes components of the ...

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Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection

lncRNA

Long non-coding RNAs (lncRNAs) are rapidly emerging as important regulators of a diverse array of cellular functions. Here, Columbia University researchers describe a meta-analysis of two independent RNA-seq studies to identify lncRNAs that are differentially expressed upon HIV-1 infection. Only three lncRNA genes exhibited altered expression of ≥ 2-fold in HIV-1-infected cells. Of these, the uncharacterized lncRNA LINC00173 was chosen ...

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