Monthly Archives: July 2017

Researchers Show Curcumin Protects Against Chemoresistant Pancreatic Cancer Through lncRNA

lncRNA

Curcumin is known for its powerful anti-inflammatory and antioxidant benefits, but a new study by researchers at Baylor Scott & White Research Institute reveals an additional benefit: its potential to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC), a common but aggressive form of cancer in the pancreas. The study, “Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit ...

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Long Noncoding RNA and Cancer: A New Paradigm

lncRNA

In addition to mutations or aberrant expression in the protein-coding genes, mutations and misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to play major roles in cancer. Genome-wide association studies of tumor samples have identified a large number of lncRNAs associated with various types of cancer. Alterations in lncRNA expression and their mutations promote tumorigenesis and metastasis. ...

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Identification of four prognostic lncRNAs for survival prediction of patients with hepatocellular carcinoma

lncRNA

As the fifth most common cancer worldwide, Hepatocellular carcinoma (HCC) is also the third most common cause of cancer-related death in China. Several lncRNAs have been demonstrated to be associated with occurrence and prognosis of HCC. However, identification of prognostic lncRNA signature for HCC with expression profiling data has not been conducted yet. With the reuse of public available TCGA ...

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Post-doc position available – characterizing lncRNA function during chondrogenesis

rna-seq

Analysis of long non coding RNAs in cartilage formation and homeostasis Employer – Shriners Hospitals for Children Portland, Oregon Location – Shriners Hospital for Children, Portland, Oregon Salary – Salary will be based on the current NIH guidelines for postdoctoral salaries Posted – July 17 2017 Discipline – Life Sciences, Health Sciences, Regenerative Medicine Position Type – Full Time Organization Type – ...

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Neat1 is a p53-inducible lincRNA essential for transformation suppression

lncrna

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, researchers at Stanford University School of Medicine leveraged p53 ChIP-seq (chromatin immunoprecipitation [ChIP] combined with high-throughput sequencing) and RNA-seq ...

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lncRNAs and MYC – An Intricate Relationship

lncrna

Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression networks, acting either at the transcriptional level, by influencing histone modifications, or at the post-transcriptional level, by controlling mRNA stability and translation. Among the gene expression networks known to influence the process of oncogenic transformation, the one controlled by the proto-oncogene MYC is one of the most frequently ...

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LPI-ETSLP – lncRNA-protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction

RNA-protein interactions are essential for understanding many important cellular processes. In particular, lncRNA-protein interactions play important roles in post-transcriptional gene regulation, such as splicing, translation, signaling and even the progression of complex diseases. However, the experimental validation of lncRNA-protein interactions remains time-consuming and expensive, and only a few theoretical approaches are available for predicting potential lncRNA-protein associations. Here, researchers from ...

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The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

lncRNA

Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these molecules in cardiac fibrosis is limited. Using an integrated genomic screen, researchers at the University of Lausanne Medical School identified Wisper (Wisp2 super-enhancer-associated RNA) as a cardiac fibroblast-enriched lncRNA that regulates cardiac fibrosis after injury. Wisper expression was ...

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