Monthly Archives: March 2017

LncATLAS – a database for subcellular localisation of long noncoding RNAs

lncRNA

The subcellular localisation of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localisation of newly-discovered lncRNAs involves time-consuming and costly experimental methods. Researchers from the Centre for Genomic Regulation and the University of Bern have created “LncATLAS”, a comprehensive resource of lncRNA localisation in human cells based on RNA-sequencing datasets. Altogether, 6768 GENCODE-annotated lncRNAs are ...

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Call for papers (Non-Coding RNA journal, MDPI)

lncRNA

ncRNA is a rapidly growing field in which new research methods are continuously appearing. With this Special Issue, we aim to collect a selection of articles on newly developed techniques of special interest for researchers in the ncRNA field. We will consider manuscripts that report on new experimental methods, as well as reviews of exceptional interest that focus on newly ...

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Impact of Dietary Interventions on Noncoding RNA Networks

lncRNA

Dietary interventions dramatically affect metabolic disease and lifespan in various aging models. Here, researchers from the Shanghai Institutes for Biological Sciences profiled liver microRNA (miRNA), coding, and long non-coding RNA (lncRNA) expression by high-throughput deep sequencing in mice across multiple energy intake and expenditure interventions. Strikingly, three dietary intervention network design patterns were uncovered: (1) lifespan-extending interventions largely repressed the ...

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Post-doc Position Available – Epigenetic Alteration of Long Non-coding RNA

lncRNA

Ref. : 201601691 Posting Title : Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA Department : Department of Medicine Closing Date : April 13, 2017 Applications are invited for appointment as Post-doctoral Fellow in Epigenetic Alteration of Long Non-coding RNA in the Department of Medicine, to commence as soon as possible for three years, with the possibility of renewal. ...

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Seven LncRNA-mRNA based risk score predicts the survival of head and neck squamous cell carcinoma

lncrna

Dysregulation of mRNAs and long non-coding RNAs (lncRNAs) is one of the most important features of carcinogenesis and cancer development. However, studies integrating the expression of mRNAs and lncRNAs to predict the survival of head and neck squamous cell carcinoma (HNSC) are still limited, hitherto. In current work, researchers at the Zhejiang University School of medicine identified survival related mRNAs ...

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Translating the ribosome’s grim role

A large number of long noncoding RNAs (lncRNA) have been found associating with the ribosome, the protein-making machinery in the cytoplasm. What the so-called ‘noncoding’ RNAs are doing on the ribosome, whose main job is to translate RNA into protein, has puzzled the A*STAR researchers who discovered them. The answer could be macabre, suggest cell biologist, Leah Vardy, at the ...

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Lncident – A Tool for Rapid Identification of Long Noncoding RNAs

lncrna

More and more studies have demonstrated that long noncoding RNAs (lncRNAs) play critical roles in diversity of biological process and are also associated with various types of disease. How to rapidly identify lncRNAs and messenger RNA is the fundamental step to uncover the function of lncRNAs identification. Researchers at Jilin University have devloped a novel method for rapid identification of ...

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Long Non-coding RNAs in Gastric Cancer: A True Relationship or miR Chance?

Long non-coding RNAs (lncRNAs) are gradually drawing the attention of the cancer research community due to their pivotal involvement in tumorigenesis and tumor progression. These non-protein coding, >200 nucleotides long transcripts are aberrantly expressed in the majority of human malignancies, including gastric cancer (GC). The discovery that lncRNAs are severely deregulated across different human malignancies has prompted the pursuit of ...

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Linking lncRNA to autoimmune diseases

lncRNA

News Medical Life Sciences – An interview with Dr. Chase Spurlock, CEO, IQuity, conducted by April Cashin-Garbutt, MA (Cantab) What are long non-coding RNAs (lncRNAs) and how do they differ from messenger RNAs (mRNAs)? Well, the central dogma of biology states that DNA makes RNA and RNA makes proteins. However, there are many different types of RNAs, and only one ...

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Post-doc position available – post-transcriptional roles of candidate long noncoding RNAs

lncRNA

Research Fellow Vacancy Ref: : 039227 Closing Date : 14-Apr-2017 Contact Person : IGMM HR Contact Number : 0131 651 8685 Contact Email : igmmhr@igmm.ed.ac.uk We are looking for a self-motivated, enthusiastic Research Fellow to join the group of Professor Chris Ponting. Job Purpose You would be joining an internationally successful research group who are investigating the post-transcriptional roles of ...

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