Monthly Archives: January 2017

lncRNA ANRIL regulates VEGF expression and function in diabetic retinopathy

Long noncoding RNAs (lncRNAs) previously thought to be “dark matter” of the genome, play key roles in various biological processes. The lncRNA ANRIL is located at a genetic susceptibility locus for coronary artery diseases and type 2 diabetes. We examined the role of ANRIL in diabetic retinopathy, through study of its regulation of VEGF both in vitro and in vivo. ...

Read More »

Post-doc position available – lncRNAs in epigenetics

lncRNA

LANL has an intellectually diverse environment and demands creative, innovative and pioneering solutions. LANL is multidisciplinary with expertise in chemistry, materials science, bioscience, physics, engineering, computer science, social science and many other fields. As a national laboratory, high priority is placed in interdisciplinary studies. Facilities include a large number of supercomputers, high-throughput biochemistry, and next-generation sequencing, as well as many ...

Read More »

Immunobiology of Long Noncoding RNAs

lncRNAs

The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of genes, the products of which combat infectious microorganisms, ...

Read More »

Of the RNAs expressed at different levels in the autism brains, 60 are long non-coding RNAs

exosome

from Spectrum News by Nicholette Zeliadt The brains of people with autism show a distinct molecular signature, according to the largest-yet postmortem study of people with the condition1. The signature reflects alterations in how genes are pieced together and expressed. The findings confirm and extend those from two smaller studies of autism brains — one from 2011 by the same ...

Read More »

Three-lncRNA signature – a novel biomarker for the accurate prognosis prediction HNSCC

lncRNA

Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC). Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial ...

Read More »

Identification and comparison of long non-coding RNAs in the silk gland between the domestic and wild silkworms

lncRNA

Under long-term artificial selection, the domestic silkworm (Bombyx mori) has increased its silk yield tremendously in comparison with its wild progenitor, Bombyx mandarina. However, the molecular mechanism of silk yield increase is still unknown. Comparative analysis of long non-coding RNAs (lncRNAs) may provide some insights into understanding this phenotypic variation. In this study, using the RNA-seq data of silk gland ...

Read More »

Transposable elements (TEs) contribute to stress-related long intergenic noncoding RNAs in Plants

lncRNA

Noncoding RNAs have been extensively described in plant and animal transcriptomes by using high-throughput sequencing technology. Of these non-coding RNAs, a growing number of long intergenic noncoding RNAs (lincRNAs) have been described in multicellular organisms, however the origins and functions of many lincRNAs remain to be explored. In many eukaryotic genomes, transposable elements (TEs) are widely distributed and often account ...

Read More »

Long Noncoding RNAs in Pathological Cardiac Remodeling

lncRNA

DNA makes RNA, RNA makes protein, and protein makes us. This central dogma of life provides a simple description how an organism develops: DNA serves as a blueprint of the genetic information, and proteins are its functional and structural manifestation, whereas RNA mediates this process as a plotted construction plan. However, the relation between the genetic code and its biological ...

Read More »

Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability

Cells communicate with one another to create microenvironments and share resources. One avenue by which cells communicate is through the action of exosomes. Exosomes are extracellular vesicles that are released by one cell and taken up by neighbouring cells. But how exosomes instigate communication between cells has remained largely unknown. Researchers from the University of New South Wales present evidence ...

Read More »

Post-doc Position Available – Molecular Mechanisms of Gene Regulation

lncRNA

Position Title: Postdoctoral Research Associate_Calabrese Lab Vacancy ID: PDS001253 Department: Pharmacology – 424001 Position Type: Postdoctoral Scholar Full-time/Part-time: Full Time FTE: 1.0 Estimated Duration of Appointment: 12 Months Posting Open Date: 03/02/2016 Open Until Filled: Yes Work Location: Chapel Hill, NC Position Summary The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by ...

Read More »