Monthly Archives: December 2016

lincRNAs Display Distinctive Patterns of Transcription and RNA Processing

lncRNA

Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been ascribed to lincRNAs, their synthesis and turnover remain poorly characterized. Here, University of Oxford researchers define systematic differences in transcription and RNA processing between protein-coding and lincRNA genes in human HeLa cells. This is based on ...

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Research Reveals the Importance of Long Non-Coding RNA Regulating Cellular Processes

lncRNA

Scientific research over the past decade has concentrated almost exclusively on the 2 percent of the genome’s protein coding regions, virtually ignoring the other 98 percent, a vast universe of non-coding genetic material previously dismissed as nothing more than ‘junk.’ Now, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) reveals that one type — called long ...

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Functions of long intergenic non-coding (linc) RNAs in plants

lncRNA

Whole transcriptome analyses in many organisms have revealed that most transcribed RNAs do not encode proteins. These non-coding RNAs likely contribute to the regulation of gene expression during the development of multicellular organisms. In eukaryotes, the roles of small RNAs, one class of non-coding RNAs, in transcriptional and post-transcriptional regulation have been well characterized. However, the functions of a second ...

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Post-doc Position Available – Biochemistry and Molecular Biology

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Job Title: Post Doctoral Associate (Biochemistry and Molecular Biology) Pay Grade: r5 Position Number: P100005691 Department / Hospital: Biochemistry & Molecular Biology 11 -STA The University of Miami Miller School of Medicine’s Department of Biochemistry and Molecular Biology has an opportunity for a Post-Doctoral Associate under the supervision of Dr. Stephen Lee, Professor of Biochemistry and Molecular Biology. Research for ...

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Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

lncRNA

Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions are profoundly heterogeneous but may converge on common pathways that are not yet well understood. Here, through post-mortem genome-wide transcriptome analysis of the largest cohort of samples analysed so far, researchers from UCLA interrogate the noncoding transcriptome, alternative splicing, and upstream molecular regulators to broaden our understanding of molecular convergence ...

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Long noncoding RNAs in the p53 network

lncRNA

The tumor-suppressor protein p53 is activated in response to numerous cellular stresses including DNA damage. p53 functions primarily as a sequence-specific transcription factor that controls the expression of hundreds of protein-coding genes and noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). While the role of protein-coding genes and miRNAs in mediating the effects of p53 has been extensively ...

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The lncRNA HOTAIR impacts differentiation of mesenchymal stem cells via triple helix formation

There is a growing perception that long non-coding RNAs (lncRNAs) modulate cellular function. In this study, researchers from RWTH University Medical School analyzed the role of the lncRNA HOTAIR in mesenchymal stem cells (MSCs) with particular focus on senescence-associated changes in gene expression and DNA-methylation (DNAm). HOTAIR binding sites were enriched at genomic regions that become hypermethylated with increasing cell culture ...

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UCSF CRISPR Study Reveals Unexpected Roles of Long Non-Coding RNAs

lncRNA

High-Throughput Screening Platform Finds that Distinct Non-Coding RNAs are Essential to the Growth of Different Cancer Cell Types UC San Francisco researchers have taken a major step toward understanding the function of the tens of thousands of human genes that do not code for proteins, a phenomenon considered one of the key remaining mysteries of the human genome. New findings ...

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Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and progression. Researchers from Shandong University aimed to identify a panel of lncRNAs for the diagnosis and recurrence prediction in bladder cancer (BC). The expression of 13 candidate lncRNAs was investigated in 80 BC and matched adjacent normal tissues via quantitative real-time PCR. The differentially expressed lncRNAs ...

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Featured lncRNA Job – Head of Translational Development

lncrna

RaNA Therapeutics, located in Cambridge, Massachusetts, is pioneering the discovery and development of a new class of RNA-based therapeutics that selectively activate protein expression. We focus on developing treatments for diseases with a significant unmet need that are difficult or impossible to address with existing technologies. Our lead programs include the upregulation of SMN2 for the treatment of Spinal Muscular ...

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