Monthly Archives: October 2016

The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells

Numerous genomic imprinting loci are regulated by long non-coding RNA (lncRNA). University of Lille researchers have previously identified a new lncRNA at the H19/IGF2 locus transcribed in H19 antisense orientation and named 91H. This RNA is conserved among mammals. In mice, 91H regulates positively IGF2 expression from a novel promoter. However, in human the function of 91H at the H19/IGF2 ...

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Noncoding RNAs – From Disease to Targeted Therapeutics

lncRNA

February 5—9, 2017 Fairmont Banff Springs, Banff, Alberta, Canada joint with the meeting on Protein-RNA Interactions: Scale, Mechanisms, Structure and Function of Coding and Noncoding RNPs (J6) Scientific Organizers: Kevin V. Morris, Archa Fox and Paloma Hoban Giangrande Sponsored by Cell Research and Ionis Pharmaceuticals, Inc. BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more ...

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lncRNAs add a new dimension to the HIV-host interplay

lncRNA

Studying the effects of HIV infection on the host transcriptome has typically focused on protein-coding genes. However, recent advances in the field of RNA sequencing revealed that long non-coding RNAs (lncRNAs) add an extensive additional layer to the cell’s molecular network. Here, researchers from Ghent University performed transcriptome profiling throughout a primary HIV infection in vitro to investigate lncRNA expression ...

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Senior scientist position in non-coding RNA in cardiovascular disease is available

Senior Scientist Vacancy Ref: : 037881 Closing Date : 22-Nov-2016 Contact Person : Contact Number : Contact Email : Andy.Baker@ed.ac.uk   A grade 8 or 9 senior scientist position in non-coding RNA in cardiovascular disease is available to join the Centre for Cardiovascular Sciences, aligned with the British Heart Foundation Chair held by Professor Andrew H Baker. The post is ...

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HULC – an oncogenic long non-coding RNA in human cancer

lncRNA

Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up-regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC ...

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Featured lncRNA Job – Role of Non-coding RNAs in Cancer

lncRNA

The Departments of Biomedical Informatics, Systems Biology and Medicine at Columbia University  in NY are seeking a highly motivated Research Associate to join the laboratories of Drs. Raul Rabadan and Kenneth Olive to study the role of non-coding RNAs in cancer. The successful candidate will join an interdisciplinary team of researchers with expertise in computational and experimental biology. We are ...

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Long non-coding RNA MALAT1 is induced by hypoxia

lncRNA

Long thought to be “junk DNA”, in recent years it has become clear that a substantial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA (lncRNA). Like mRNA, lncRNA can also be spliced, capped, and polyadenylated, affecting a multitude of biological processes. While the molecular mechanisms underlying the function of lncRNAs have just begun to be elucidated, ...

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Metastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets

lncRNA

Long non-coding RNAs (lncRNAs), a newly discovered class of ncRNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that lncRNAs are involved in diverse physiological and pathophysiological processes, such as cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Aberrant expression of lncRNAs frequently occurs in gastrointestinal cancer ...

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RNA-DNA Triplex Formation by Long Noncoding RNAs

lncRNA

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological processes through various mechanisms that are not fully understood. Proposed mechanisms include regulation based on RNA-protein interactions, as well as RNA-RNA interactions and RNA-DNA interactions. Here, researchers from Kyoto University focus on one possible mechanism that lncRNA might be using to impact biological function, the RNA-DNA triplex ...

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Lung Cancer Research Foundation Awards Grant to lncRNA Researcher

lncRNA

The Lung Cancer Research Foundation (LCRF™) announced the awardees of its 2016 Scientific Grant Program at the Eleventh Annual Lung Cancer Awareness Luncheon, held on Monday, October 17, at The Pierre in New York City. In another record-breaking year, LCRF awarded $2.2 million in research grants to 15 researchers as part of the LCRF Scientific Grant Program, an annual program ...

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