Monthly Archives: August 2016

Understanding long non-coding RNAs using comparative genomics

Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a multitude of pathways across species, but it remains challenging to understand which of them are important and how their functions are performed. Comparative sequence analysis has been instrumental for studying proteins and small RNAs, but the rapid evolution of lncRNAs poses new challenges that demand new ...

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Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical cancer

lncRNA

Researchers from the University of Tokyo to examine the association between the expression of long non‑protein‑coding RNAs (lncRNAs) and clinical prognosis in the pretreatment formalin-fixed, paraffin-embedded (FFPE) tissue samples of cervical squamous cell carcinoma patients that underwent platinum‑based chemoradiation therapy. Between 2001 and 2013, 49 consecutive patients with squamous cell cervical carcinoma were selected for the present study (median follow‑up period, 44.1 months). ...

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lncRNA MYU plays a critical role in the proliferation and tumorigenicity of colon cancer cells.

lncRNA

Aberrant activation of Wnt/β-catenin signaling is a major driving force in colon cancer. Wnt/β-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and tumorigenesis. c-Myc regulates multiple biological processes through its ability to directly modulate gene expression. Here, researchers from the University of Tokyo identify a direct target of c-Myc, termed MYU, and show that ...

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PCAT14 is a Prognostic Biomarker in Prostate Cancer

lncRNA

Rapid advances in the discovery of long noncoding RNAs (lncRNAs) have identified lineage- and cancer-specific biomarkers that may be relevant in the clinical management of prostate cancer (PCa). Here University of Michigan researchers assembled and analyzed a large RNA-seq dataset, from 585 patient samples, including benign prostate tissue and both localized and metastatic PCa to discover and validate differentially expressed ...

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Investigation of novel LPS-induced differentially expressed long non-coding RNAs in endothelial cells

lncRNA

The molecular mechanisms responsible for sepsis-induced endothelial dysfunction leading to an elevated risk of cardiovascular diseases remain undefined. Endotoxic or septic shock is a potentially lethal complication of systemic infection by Gram-negative bacteria. Lipopolysaccharide (LPS) is a critical glycolipid component of the outer wall of Gram-negative bacteria, and many of the sepsis-associated cellular signals by Gram-negative bacteria are attributed to ...

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Long Non-Coding RNAs Linked to Development and Progression of Prostate Cancer

lncRNA

from BiotechDaily International –  Cancer researchers have found a link between a number of long non-coding RNAs and the development and progression of prostate cancer. Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. This somewhat arbitrary limit distinguishes lncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar ...

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Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

lncRNA

Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure. Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in heart failure remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of ...

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Androgen-responsive lncRNAs are diagnostic and prognostic markers for prostate cancer

lncRNA

Prostate cancer (PCa) is a leading cause of mortality among males. Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that may act as biomarkers and therapeutic targets. In this study, researchers at Fudan University firstly conducted analysis of global lncRNA expression patterns by using their own cohort (GSE73397) and two public available gene expression datasets: The Cancer Genome Atlas ...

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lncRNAs Maintain Equilibrium Between Fighting Infection, Inflammatory Havoc

lncRNA

Penn Study Identifies New Drug Target for Inflammatory Disorders PHILADELPHIA – Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of ...

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