Monthly Archives: June 2016

Long non-coding RNA – computational models

lncRNA

LncRNAs have attracted lots of attentions from researchers worldwide in recent decades. With the rapid advances in both experimental technology and computational prediction algorithm, thousands of lncRNA have been identified in eukaryotic organisms ranging from nematodes to humans in the past few years. More and more research evidences have indicated that lncRNAs are involved in almost the whole life cycle ...

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Transcriptome sequencing uncovers a three-long noncoding RNA signature in predicting breast cancer survival

lncRNA

Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. The aim of this study was to identify a lncRNA signature that can predict breast cancer patient survival. RNA expression data from 1064 patients were downloaded from The Cancer Genome Atlas project. Cox regression, Kaplan-Meier, and receiver operating characteristic (ROC) analyses were performed to construct a model for predicting the ...

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Long noncoding RNA lincRNA-EPS as a repressor of inflammatory responses

lncRNA

Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, researchers at the University of Massachusetts Medical School identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely regulated in macrophages to control the expression of immune response genes (IRGs). Transcriptome analysis of macrophages from lincRNA-EPS-deficient ...

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Post-doc position available in Long Noncoding RNA biology specializing in RNA epigenetics

lncRNA

Type of employment: Fixed-term employment, up to four years Extent: 100 % Location: Institute of Biomedicine, Gothenburg First day of employment: By agreement Reference number: PER 2016/266 Institute of Biomedicine is a huge super department with vast interest in several disciplines of biological research. It employs more than 400 people, including 110 PhD students. Insitute of Biomedicine is actively engaged ...

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Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis

lncRNA

Long intergenic noncoding RNAs (lincRNAs) are a relatively new class of non-coding RNAs that have the potential as cancer biomarkers. To seek a panel of lincRNAs as pan-cancer biomarkers, researchers at the University of Hawaii at Manoa have analyzed transcriptomes from over 3300 cancer samples with clinical information. Compared to mRNA, lincRNAs exhibit significantly higher tissue specificities that are then ...

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Long non-coding RNA and their clinical perspective

lncRNA

Long non coding RNA and Their clinical perspective from Mohit Goswami Central Dogma of Molecular Biology “The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to either protein or nucleic acid.” -Francis Crick, 1958

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Deciphering the function of non-coding RNAs in prostate cancer

lncRNA

The advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to be of particular importance in human pathogenesis, including cancer. The aberrant expression of ncRNAs is a feature of prostate cancer, as they promote tumor-suppressive or oncogenic activities, controlling multicellular ...

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A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines

lncRNA

Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and microRNAs. However, there is limited data on the role and expression of long noncoding RNAs (lncRNAs) in prostate cancer exosomes. Researchers from the ...

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FMLNCSIM – fuzzy measure-based lncRNA functional similarity calculation model

lncRNA

Accumulating experimental studies have indicated the influence of lncRNAs on various critical biological processes as well as disease development and progression. Calculating lncRNA functional similarity is of high value in inferring lncRNA functions and identifying potential lncRNA-disease associations. However, little effort has been attempt to measure the functional similarity among lncRNAs on a large scale. Now, researchers have developed a ...

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Is there a link between long noncoding RNAs and depression?

lncrna

The major depressive disorder (MDD) is a relatively common mental disorder from which that hundreds of million people have suffered, leading to displeasing life quality, which is characterized by health damage and even suicidal thoughts. The complicated development and functioning of MDD is still under exploration. Long noncoding RNA (lncRNAs) are highly expressed in the brain, could affect neural stem ...

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