Monthly Archives: May 2016

A functional GBM long non-coding RNA-mediated competitive endogenous RNA network

lncRNA

Glioblastoma multiforme (GBM) is a highly malignant brain tumor associated with a poor prognosis. Cross-talk between competitive endogenous RNAs (ceRNAs) plays a critical role in tumor development and physiology. In this study, researchers at Xiangya Hospital present a multi-step computational approach to construct a functional GBM long non-coding RNA (lncRNA)-mediated ceRNA network (LMCN) by integrating genome-wide lncRNA and mRNA expression ...

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Featured lncRNA Job – Research Assistant in Molecular and Cellular Biology

lncrna

Job Category: Fulltime Regular Job Summary: We are seeking a highly motivated and dependable individual to join our integrative computational and experimental team in characterizing the functions and mechanisms of lncRNAs. Specifically, this person will help to develop and optimize methods and generate data for understanding interactions between RNA, DNA and protein in mammalian cells. This work will include experiments ...

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Long non-coding RNAs as novel therapeutic targets in cancer

lncRNA

As a result of the explosion of large-scale genome sequencing projects, we have gained great insights into the evolution of complex organisms. Perhaps, one of the most unexpected outcomes of these studies was that the human genome contains only about 20,000 protein-coding genes, which occupy less than 3% of human DNA. Most of these genes also appear rather well conserved ...

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lincRNAs linked to increased children’s risk of blood infection

lncRNA

A team led by Oxford University has identified genes that make certain children more susceptible to invasive bacterial infections by performing a large genome-wide association study in African children. Bacteraemia, bacterial infection of the bloodstream, is a major cause of illness and death in sub-Saharan Africa but little is known about whether human genetics play a part. The leading bacterial ...

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The lncRNA PAUPAR suppresses tumourigenesis in melanoma

lncRNA

Uveal melanoma (UM) is the most common primary intraocular tumour in adults and has a high incidence. Nearly 50% of patients with UM develop metastases after diagnosis. Long non-coding RNAs (lncRNAs) are involved in both oncogenic and tumour suppression pathways. Researchers at Shanghai JiaoTong University School of Medicine show that lncRNA PAUPAR is present at low levels in UM tissues ...

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The lncRNA PANDAR plays oncogenic roles in bladder cancer

lncRNA

Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-coding RNA that acts as a potential biomarker and involves in development of multiple cancers. However, the clinical significance and molecular mechanism of PANDAR in bladder cancer is still unknown. In ...

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Understanding the Functions of Long Non-Coding RNAs through Their Higher-Order Structures

lncRNA

Although thousands of long non-coding RNAs (lncRNAs) have been discovered in eukaryotes, very few molecular mechanisms have been characterized due to an insufficient understanding of lncRNA structure. Therefore, investigations of lncRNA structure and subsequent elucidation of the regulatory mechanisms are urgently needed. However, since lncRNA are high molecular weight molecules, which makes their crystallization difficult, obtaining information about their structure ...

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The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various Cancers

lncRNA

Malignant tumors are harmful to human health and have become a leading cause of mortality worldwide. According to the “global cancer report 2012” released by the World Health Organization (WHO), the global incidence of cancer is rapidly increasing. Early diagnosis and treatment are critical for the research and clinical treatment of tumors. Furthermore, tumor molecular markers are of great practical ...

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Comparative expression dynamics of intergenic long noncoding RNAs (lncRNAs) in the genus Drosophila

lncRNA

Thousands of long noncoding RNAs (lncRNAs) have been annotated in eukaryotic genomes, but comparative transcriptomic approaches are necessary to understand their biological impact and evolution. To facilitate such comparative studies in Drosophila, researchers at the University of Maryland identified and characterized lncRNAs in a second Drosophilid – the evolutionary model D. pseudoobscura. Using RNA-Seq and computational filtering of protein-coding potential, ...

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The lncRNA SLNCR1 Mediates Melanoma Invasion

lncRNA

 Increased expression of SLNCR1 is associated with reduced overall melanoma survival  SLNCR1 knockdown decreases melanoma invasion  The transcription factors AR and Brn3a bind adjacent sequences in SLNCR1  SLNCR1, AR, and Brn3a are all required for upregulating the matrix metalloproteinase MMP9 Long non-coding RNAs (lncRNAs) have been implicated in numerous physiological processes and diseases, most notably cancers. However, little is known ...

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