Monthly Archives: December 2015

DECKO – Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs

lncRNA

For some time, scientists have been seeking a more efficient and reliable way to edit the genome and modify it to suit any need. A technique called CRISPR-Cas9 was recently launched as the solution to this problem, and has since taken a position as one of the most revolutionary techniques in molecular biology. Although CRISPR-Cas9 is much more powerful than ...

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Long noncoding RNAs in lung cancer – what we know in 2015

lncRNA

Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological ...

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CANTATAdb – a Collection of Plant Long Non-coding RNAs

lncRNA

Long non-coding RNAs (lncRNAs) represent a class of potent regulators of gene expression that are found in a wide array of eukaryotes, however, our knowledge about these molecules in plants is still very limited. In particular, a number of model plant species still lack comprehensive datasets of lncRNAs and their annotations and very little is known about their biological roles. ...

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deepBase v2.0 – identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs from deep-sequencing data

lncRNA

Small non-coding RNAs (e.g. miRNAs) and long non-coding RNAs (e.g. lincRNAs and circRNAs) are emerging as key regulators of various cellular processes. However, only a very small fraction of these enigmatic RNAs have been well functionally characterized. In this study, we describe deepBase v2.0, an updated platform, to decode evolution, expression patterns and functions of diverse ncRNAs across 19 species. ...

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Symbiosis with Ancient Viruses Critical for Human Development

lncRNA

from Bioscience Technology by Cynthia Fox In recent years humans have come to understand we are not just about Darwinian natural selection, but symbiosis. For two billion years, there were only bacteria and archaea. Then a single archaea swallowed a bacteria in such a way the bacteria became its powerpack. Complex life exploded out of this symbiosis. Remnants of that ...

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