Monthly Archives: September 2015

C-It-Loci – a knowledge database for tissue-enriched loci

lncRNA

Increasing evidences suggest that most of the genome is transcribed into RNAs, but many of them are not translated into proteins. All those RNAs that do not become proteins are called ‘non-coding RNAs (ncRNAs)’, which outnumbers protein-coding genes. Interestingly, these ncRNAs are shown to be more tissue specifically expressed than protein-coding genes. Given that tissue-specific expressions of transcripts suggest their ...

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Penn/Arizona Team to Study Little-understood lncRNA Molecules

lncRNA

There is a theory that RNA, instead of DNA, is the original building block of all life. Yet many RNA molecules remain mysterious, their true nature and function little understood. Now, with an award of more than $2.5 million from the National Science Foundation’s Plant Genome Research Program, the University of Pennsylvania’s Brian Gregory will join two scientists from the ...

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Co-LncRNA – investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data

lncRNA

Long non-coding RNAs (lncRNAs) are emerging as key regulators of diverse biological processes and diseases. However, the combinatorial effects of these molecules in a specific biological function are poorly understood. Identifying co-expressed protein-coding genes of lncRNAs would provide ample insight into lncRNA functions. To facilitate such an effort, researchers at Harbin Medical University, China have developed Co-LncRNA, which is a ...

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LncReg – a reference resource for lncRNA-associated regulatory networks

lncRNA

Long non-coding RNAs (lncRNAs) are critical in the regulation of various biological processes. In recent years, plethora of lncRNAs have been identified in mammalian genomes through different approaches, and the researchers are constantly reporting the regulatory roles of these lncRNAs, which leads to complexity of literature about particular lncRNAs. Therefore, for the convenience of the researchers, we collected regulatory relationships ...

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Scientists discover long-sought genetic mechanism for cancer progression

lncRNA

Action of a key lncRNA different in colon cancer versus normal colon tissue Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer. The researchers found that ...

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