Monthly Archives: August 2015

Upcoming Webinar – Knockdown of lncRNAs: exploring RNAi and antisense oligo methods

lncRNA

Date: Tuesday, August 25, 2015 Time: Session 1: 9:00–10:00 am CDT (UTC-5) Session 2: 1:00–2:00 pm CDT (UTC-5) Presenter: Kim Lennox, MSc Program overview Thousands of different long non-coding RNAs (lncRNAs) exist in mammalian cells. lncRNAs do not encode proteins but can be very important for cell function. Studying their functions can be difficult because of their diverse modes of ...

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Featured lncRNA – PCAT5

lncRNA

Castration-resistant prostate cancer (CRPC) that arise after the failure of androgen blocking therapies cause most of the deaths from prostate cancer (PC), intensifying the need to fully understand CRPC pathophysiology. A team led by researchers at MD Anderson Cancer Center characterized the transcriptomic differences between untreated PC and locally recurrent CRPC and they report the identification of 145 previously unannotated ...

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mi & lncRNA World 2015 Conference

lncRNA

Deepen Your Mechanistic Understanding to Harness the Biomarker, Diagnostic & Therapeutic Applications of mi & lncRNA’s mi & lncRNA World 2015 will enable you to deepen and broaden your understanding of miRNA and lncRNA mechanisms and functionality. Heighten your focus on the basic, translational, and clinical opportunities of non-coding entities to bridge the gap between basic research and clinical relevance. With the lncRNA field ...

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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures

lncRNA

Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. Researchers from the University of Gothenburg have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one of the chromatin-interacting lncRNAs, MEG3,  they explored the mechanisms by which lncRNAs target chromatin. ...

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