Monthly Archives: June 2015

Total RNA-Seq Identifies Long Non-Coding RNAs Involved in Abiotic Stress Response in M. Truncatula

lncRNA

Long non-coding RNAs (lncRNAs) have been shown to play crucial regulatory roles in diverse biological processes involving complex mechanisms. However, information regarding the number, sequences, characteristics and potential functions of lncRNAs in plants is so far overly limited. For that reason, researchers from The Institute of Botany of the Chinese Academy of Sciences used total RNA-Seq to identify a total ...

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zflncRNApedia – A Comprehensive Online Resource for Zebrafish Long Non-Coding RNAs

lncRNA

Recent transcriptome annotation using deep sequencing approaches have annotated a large number of long non-coding RNAs in zebrafish, a popular model organism for human diseases. These studies characterized lncRNAs in critical developmental stages as well as adult tissues. Each of the studies has uncovered a distinct set of lncRNAs, with minor overlaps. The availability of the raw RNA-Seq datasets in ...

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LncRNA Regulator Of Brown Fat Identified

lncRNA

from Asian Scientist AsianScientist (Apr. 29, 2015) – A study by researchers in Duke-NUS Graduate Medical School Singapore (Duke-NUS) has shown a new way that brown fat, a potential obesity-fighting target, is regulated in the body. This finding gives researchers and weight-loss companies a possible therapeutic target for obesity. In a Cell Metabolism article, Duke-NUS Assistant Professor Lei Sun and ...

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Agilent Collaborates with Ghent University to Incorporate LNCipedia Content to Human v3 Gene Expression Microarray

lncRNA

SANTA CLARA, Calif.–(BUSINESS WIRE)–Agilent Technologies Inc. (NYSE:A) today announced updates to its SurePrint gene expression microarrays for messenger RNA profiling applications for human, mouse and rat models. The updates improve coding and noncoding content, which will provide up-to-date tools for researchers to investigate expression patterns on a highly accessible platform. “Through the high performance and quantitative concordance of our gene ...

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An update on LNCipedia – a database for annotated human lncRNA sequences

lncRNA

LNCipedia collects long non-coding RNA sequences and annotation from different sources. In version 3.0, over 90,000 new transcripts were added to the database. 6917 of these transcripts were obtained from RefSeq by filtering for accession prefix (NR_) and size (200bp). This filtering strategy however, does not confine to long non-coding RNAs and also yields transcripts associated with protein coding genes. ...

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PredcircRNA: computational classification of circular RNA from other long non-coding RNA using hybrid features

lncRNA

Recently circular RNA (circularRNA) has been discovered as an increasingly important type of long non-coding RNA (lncRNA), playing an important role in gene regulation, such as functioning as miRNA sponges. So it is very promising to identify circularRNA transcripts from de novo assembled transcripts obtained by high-throughput sequencing, such as RNA-seq data. In this study, researchers from the University of ...

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Unveiling a new factor that helps breast cancer cells to tolerate drugs

lncRNA

from biotechin.asia by Mohamad Moustafa Ali Breast cancer is one of the most divergent and heterogeneous genetic disorders that affects hundreds of thousands of women worldwide every year. Scientists have systematically classified breast cancer tumors into different types, whereas each type possesses different characteristic features. Among these different types, endocrine receptor-positive (ER+) is the most common one. The ER+ breast ...

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