Monthly Archives: May 2015

GermlncRNA: a unique catalogue of long non-coding RNAs and associated regulations in male germ cell development

lncRNA

Spermatogenic failure is a major cause of male infertility, which affects millions of couples worldwide. Recent discovery of long non-coding RNAs (lncRNAs) as critical regulators in normal and disease development provides new clues for delineating the molecular regulation in male germ cell development. However, few functional lncRNAs have been characterized to date. A major limitation in studying lncRNA in male ...

Read More »

Dynamic and widespread lncRNA expression in the sponge and the origin of animal complexity

lncRNA

Long non-coding RNAs (lncRNAs) are important developmental regulators in bilaterian animals. A correlation has been claimed between the lncRNA repertoire expansion and morphological complexity in vertebrate evolution. However, this claim has not been tested by examining morphologically simple animals. Here, researchers from the University of Queensland undertake a systematic investigation of lncRNAs in the demosponge Amphimedon queenslandica, a morphologically-simple, early-branching ...

Read More »

A Postdoc position is available – binding partners of non-annotated lncRNAs in vascular cells

lncRNA

A Post-doctoral position is available immediately to study the binding partners of several non-annotated lncRNAs in vascular cells of human origin. The position will require the candidate to have expertise in biochemical assays for the discovery of proteins or RNAs that interact with a number of nuclear and cytoplasmic lncRNAs found through RNA-seq of human vascular cells treated under a ...

Read More »

Featured lncRNA – PVT1

lncRNA

It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ...

Read More »