Monthly Archives: February 2015

Postdoc Position Available – Bioinformatics and Computational Biology

lncRNA

PostDoc (2 years) position in Bioinformatics and Computational Biology The Department of Science and Technology, University of Sannio, Benevento, Italy (http://www.bioinformatics.unisannio.it) Applications are invited for postdoctoral researchers (Assegno di ricerca) in Bioinformatics in the area of high throughput sequence analysis. The successful post-doc candidate will work in our group, a multidisciplinary bioinformatics team composed by computer and life sciences researchers. ...

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Annocript – a flexible pipeline for the annotation of transcriptomes also able to identify putative long noncoding RNAs

The eukaryotic transcriptome is composed of thousands of coding and long noncoding RNAs (lncRNAs). However, we lack a software platform to identify both RNA classes in a given transcriptome. Here researchers from the Anton Dohrn – Zoological Station introduce Annocript, a pipeline which combines the annotation of protein coding transcripts with the prediction of putative lncRNAs in whole transcriptomes. It ...

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Featured lncRNA – acal

lncRNA

Changes in cell shape affect many critical cellular and bodily processes, like wound healing and developmental events, and when gone awry, metastatic processes in cancer. Evolutionarily conserved signaling pathways govern regulation of these cellular changes. The Jun-N-terminal kinase pathway regulates cell stretching during wound healing and normal development. An extensively studied developmental process is embryonic dorsal closure in fruit flies, ...

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Scientists develop a novel method to suppress malaria parasite’s virulence genes, break the code of its immune evasion

Revealed: how malaria evades the immune response by using long noncoding RNA to express one gene while silencing others Up to one million people — mainly pregnant woman and young children — are killed each year  by the Plasmodium falciparum parasite, which causes the most devastating form of human malaria. Now, researchers at the Hebrew University of Jerusalem have revealed ...

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Upcoming Conference – Long Noncoding RNAs: From Evolution to Function

lncrna

Scientific Organizers: Leonard Lipovich, Jeannie T. Lee, John L. Rinn and James (Ben) Brown March 15—20, 2015 Keystone Resort, Keystone, Colorado, USA Sponsored by Cell Research, Isis Pharmaceuticals, Inc., Regeneron Pharmaceuticals, Inc. and Sarepta Therapeutics Meeting Summary It has become clear that metazoan genomes are replete with transcription from non-protein-coding regions, generating many long noncoding RNA (lncRNA) transcripts. Recent progress ...

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Junk DNA and the long non-coding RNA twist in cancer genetics

lncRNA

The central dogma of molecular biology states that the flow of genetic information moves from DNA to RNA to protein. However, in the last decade this dogma has been challenged by new findings on non-coding RNAs (ncRNAs) such as microRNAs (miRNAs). More recently, long non-coding RNAs (lncRNAs) have attracted much attention due to their large number and biological significance. Many ...

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Long Noncoding RNAs in Cardiovascular Diseases

lncRNA

In recent years, increasing evidence suggests that noncoding RNAs play important roles in the regulation of tissue homeostasis and pathophysiological conditions. Besides small noncoding RNAs (eg, microRNAs), >200-nucleotide long transcripts, namely long noncoding RNAs (lncRNAs), can interfere with gene expressions and signaling pathways at various stages. In the cardiovascular system, studies have detected and characterized the expression of lncRNAs under ...

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Post-transcriptional regulation of long noncoding RNAs in cancer

lncRNA

It is a great surprise that the genomes of mammals and other eukaryotes harbor many thousands of long noncoding RNAs (lncRNAs). Although these long noncoding transcripts were once considered to be simply transcriptional noise or cloning artifacts, multiple studies have suggested that lncRNAs are emerging as new players in diverse human diseases, especially in cancer, and that the molecular mechanisms ...

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Integrating Large-Scale RNA-Seq and CLIP-Seq Datasets Enables Study of lncRNA

Long non-coding RNAs (lncRNAs) are emerging as important regulatory molecules in developmental, physiological, and pathological processes. However, the precise mechanism and functions of most of lncRNAs remain largely unknown. Recent advances in high-throughput sequencing of immunoprecipitated RNAs after cross-linking (CLIP-Seq) provide powerful ways to identify biologically relevant protein-lncRNA interactions. In this study, researchers at Sun Yat-sen University analyzed millions of ...

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An encyclopaedic guide to the dark genome

lncRNA

from New Scientist Life by Linda Geddes From six-toed cats to miniature Spider-men, Junk DNA by Nessa Carey is a wide-ranging survey of a controversial, ever-changing field SNOW WHITE, the six-toed cat famously given to Ernest Hemingway by a ship’s captain, did not get its extra digit as the result of a freak gene mutation. In fact, extra fingers and ...

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