Monthly Archives: December 2014

Long noncoding RNAs as putative biomarkers for prostate cancer detection

lncRNA

Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. Researchers at the Sanford-Burnham Medical Research Institute identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and ...

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Long noncoding RNAs – A Novel Prognostic Marker In AML

lncRNA

COLUMBUS, Ohio – A new study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) describes a novel marker that might help doctors choose the least toxic, most effective treatment for many older patients with acute myeloid leukemia (AML).  AML occurs mainly in ...

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Postdoc position available – structural aspect of lncRNA-protein complexes

lncRNA

Location:             Grenoble, France Staff Category:       Postdoctoral Fellow Contract Duration:   2 years Reference Number:     GR_00072 Closing Date:         4 January 2015 Job Description The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy). ...

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RaNA Therapeutics comes out of stealth, with new CEO, to further RNA targeting for diseases

lncRNA

from Beta Boston by Dennis Keohane RaNA Therapeutics, a company that is using a novel approach to fight disease using RNA, is coming out of stealth today and announcing that Ronald Renaud Jr. will be the company’s new chief executive officer. Founded at the end of 2011 using technology developed by Jeannie Lee, an investigator at the Howard Hughes Medical Institute ...

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Genome-wide analysis of long noncoding RNA signature in human colorectal cancer

lncRNA

Long noncoding RNAs (lncRNAs) have been widely regarded as crucial regulators in various biological processes involved in carcinogenesis. However, the comprehensive lncRNA expression signature in colorectal cancer remains fully unknown. Researchers at Nanjing Medical University performed a high throughput microarray assay to detect lncRNA expression profile in three paired human colorectal cancer tissues and their adjacent normal tissues. Additional 90 ...

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New Angelman syndrome therapy proposed

lncRNA

from UT San Diego by Bradley J. Fikes Isis Pharma approach helps mouse models of genetic disease A potential therapy for Angelman syndrome, a baffling genetic disease that impairs intellectual development, has been proposed by scientists including researchers at Isis Pharmaceuticals. The treatment, tested in mice, activates a gene that restores some of the neurological activity reduced in Angelman syndrome, ...

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A pathophysiological view of the long non-coding RNA world

lncRNA

Because cells are constantly exposed to micro-environmental changes, they require the ability to adapt to maintain a dynamic equilibrium. Proteins are considered critical for the regulation of gene expression, which is a fundamental process in determining the cellular responses to stimuli. Recently, revolutionary findings in RNA research and the advent of high-throughput genomic technologies have revealed a pervasive transcription of ...

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