Monthly Archives: November 2014

LncRNA2Target – a database for differentially expressed genes after lncRNA knockdown or overexpression

lncRNA

Long noncoding RNAs (lncRNAs) have been emerged as critical regulators of gene expression at epigenetic, transcriptional and post-transcriptional level, yet what genes are regulated by lncRNAs remains to be characterized. To assess the effects of a specific lncRNA on gene expression, increasing researchers profiled the genome-wide or individual gene expression level changes after knocking down or overexpressing the lncRNA. However, ...

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Postdoc Position Available – Long Non-coding RNA

Postdoctoral fellow in Medical science, specifically bioinformatics and cancer genomics University of Gothenburg, Sweden Type of employment: Fixed-term employment, 2 years Extent: 100 % Location: Institute of Biomedicine, Gothenburg First day of employment: As agreed Reference number: PER 2014/466 The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge ...

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Featured Long Non-coding RNA – LOC401317

lncRNA

Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in nasopharyngeal carcinoma remains unclear. Here, ...

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Protracted Unrest Between ENCODE Researchers and Junk-DNA Advocates Goes On

lncRNA

from Evolution News and Views It’s not exactly Fergusson, Mo., but the battle between ENCODE researchers and junk-DNA holdouts goes on. Our ongoing coverage of the hostilities left off with the latter sending over their latest salvo. Now, ENCODE is back. Confident that genomes are not mostly junk, they have set their latest contender in the ring: a mouse. The ...

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The long non-coding RNA NBAT-1 is a prognostic biomarker in neuroblastoma

lncRNA

Neuroblastoma is an embryonal tumor of the sympathetic nervous system and the most common extracranial tumor of childhood. By sequencing transcriptomes of low- and high-risk neuroblastomas, we detected differentially expressed annotated and nonannotated long noncoding RNAs (lncRNAs). We identified a lncRNA neuroblastoma associated transcript-1 (NBAT-1) as a biomarker significantly predicting clinical outcome of neuroblastoma. CpG methylation and a high-risk neuroblastoma ...

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