Monthly Archives: September 2014

PLEK: a tool for predicting long non-coding RNAs and messenger RNAs based on an improved k-mer scheme

High-throughput transcriptome sequencing (RNA-seq) technology promises to discover novel protein-coding and non-coding transcripts, particularly the identification of long non-coding RNAs (lncRNAs) from de novo sequencing data. This requires tools that are not restricted by prior gene annotations, genomic sequences and high-quality sequencing. A team led by researchers at the Xidian University, present an alignment-free tool called PLEK (predictor of long ...

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Upcoming Seminar – Small and long noncoding RNAs in control of cell proliferation and differentiation

Tuesday, October 14, 2014 Anindya Dutta University of Virginia School of Medicine, Charlottesville, EUA SEMINAR | 14 OCTOBER | 12:00 | MAIN AUDITORIUM  Small and long  noncoding RNAs in control of cell  proliferation and differentiation Anindya Dutta, University of Virginia School of Medicine, Charlottesville, EUA

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Parts of genome without a known function may play a key role in the birth of new proteins

lncrna

The study analysed experiments carried out on six different species and identified almost 2,500 IncRNAs that were not in the databases Researchers in Biomedical Informatics at IMIM (Hospital del Mar Medical Research Institute) and at the Universitat Politècnica de Catalunya (UPC) have recently published a study in eLife showing that RNA called non-coding (IncRNA) plays an important role in the ...

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Long non-coding RNAs in cancer: implications for personalized therapy

Long non-coding RNAs (lncRNAs, pseudogenes and circRNAs) have recently come into light as powerful players in cancer pathogenesis and it is becoming increasingly clear that they have the potential of greatly contributing to the spread and success of personalized cancer medicine. In this concise review, the authors briefly introduce these three classes of long non-coding RNAs. We then discuss their ...

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Non-coding RNA – Zooming in on lncRNA functions

Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression; however, in contrast to transcription factors, their functional domain architecture remains poorly understood. Now, a new method has been developed to simultaneously map RNA–RNA, RNA–DNA and RNA–protein interactions at the level of individual RNA domains with increased sensitivity. Quinn et al. developed a method called domain-specific chromatin isolation ...

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Targeted Neuroblastoma Therapy One Step Closer

lncRNA

from ScienceNetwork WA by  Anika Rodgers AUSTRALIAN researchers have uncovered new targets for therapy in the childhood cancer neuroblastoma. Histone Modification Group and Children’s Cancer Institute Australia for Medical Research’s Tao Liu says the researchers have been studying neuroblastoma in the hope of developing novel treatments. “Neuroblastoma is the most common solid tumour in early childhood and it accounts for ...

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Newly Discovered Large Molecule Could be Key to Treating Heart Failure

lncRNA

from Bioresearch Online by C. Rajan, contributing writer Researchers at the Indiana University School of Medicine have just discovered a molecule which allows the heart to block a protein that creates genetic disruptions when the heart is subjected to stressful conditions, such as high blood pressure. This previously unknown molecule could help in treating and preventing heart failure. The newly ...

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Emerging Role of Long Non-Coding RNA SOX2OT in SOX2 Regulation in Breast Cancer

The transcription factor SOX2 is essential for maintaining pluripotency in a variety of stem cells. It has important functions during embryonic development, is involved in cancer stem cell maintenance, and is often deregulated in cancer. The mechanism of SOX2 regulation has yet to be clarified, but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called ...

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Penn Team Finds Ovarian Cancer Oncogene in "Junk DNA"

PHILADELPHIA — Over the years researchers have made tremendous strides in the understanding and treatment of cancer by searching genomes for links between genetic alterations and disease. This image depicts an oncogenic lncRNA FAL1 (the dragon) dysregulating gene transcription and promoting tumorigenesis. FAL1 stabilizes BMI1 (the stone) by associating with it (the dragon twine around the stone), which subsequently enhances ...

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Transcriptome sequencing uncovers altered long intergenic non-coding RNAs

Long intergenic non-coding RNAs (lncRNAs) represent an emerging and under-studied class of transcripts that play a significant role in human cancers. Due to the tissue- and cancer-specific expression patterns observed for many lncRNAs it is believed that they could serve as ideal diagnostic biomarkers. However, until each tumor type is examined more closely, many of these lncRNAs will remain elusive. ...

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