Monthly Archives: August 2014

LncRNA: A link between RNA and cancer

Unraveling the gene expression networks governing cancer initiation and development is essential while remains largely uncompleted. With the innovations in RNA-seq technologies and computational biology, long noncoding RNAs (lncRNAs) are being identified and characterized at a rapid pace. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or ...

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Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs

Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here a team led by researchers from the NYU School of Medicine investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemia (T-ALL). By ...

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Postdoc Position Available – Myc regulated lncRNAs in B-cell lymphoma

  Department Department of Pathology & Medical Biology Work location Groningen Apply no later than 14 September 2014 Working environment Project description Our lab is interested in understanding the function of non-coding RNAs in B-cell lymphoma. Besides studying microRNAs for over ten years, we more recently gained interest in the function of long non-coding RNAs in B cell lymphoma. Long ...

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A long non-coding RNA signature to improve prognosis prediction of colorectal cancer

Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. Researchers from the Shanghai Institution of Digestive Disease aimed to develop a lncRNA signature to improve prognosis prediction of colorectal cancer (CRC). Using a lncRNA-mining approach, they performed lncRNA expression profiling in large CRC ...

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs

lncRNA

The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...

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Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs

lncRNA

The role of noncoding RNAs in mammalian biology is of great interest, especially since the Encyclopedia of DNA Elements results were published. Many have studied microRNAs in the heart, but little is known about their larger cousins, long noncoding RNAs (lncRNAs). Here, researchers from the Washington University School of Medicine used genome-wide sequencing and improved bioinformatics to quantify lncRNA expression ...

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Postdoc Position Available – University of Copenhagen

Deadline for application is September 22, 2014 The fellowship is part of a newly established European non‐coding RNA training network, ‘RNatrain’ funded by th European Commission as a Marie Curie Initial Training Network (FP7). We are looking for a researcher to join the programme and the Lund Group at BRIC from January 1st 2015 or after agreement. (find out more…)

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Postdoc Position Available – University of Copenhagen

Deadline for application is September 22, 2014 The fellowship is part of a newly established European non‐coding RNA training network, ‘RNatrain’ funded by th European Commission as a Marie Curie Initial Training Network (FP7). We are looking for a researcher to join the programme and the Lund Group at BRIC from January 1st 2015 or after agreement. (find out more…)

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Researchers obtain key insights into how the internal body clock is tuned

DALLAS – August 18, 2014 – Researchers at UT Southwestern Medical Center have found a new way that internal body clocks are regulated by a type of molecule known as long non-coding RNA. Dr. Yi Liu The internal body clocks, called circadian clocks, regulate the daily “rhythms” of many bodily functions, from waking and sleeping to body temperature and hunger. They ...

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Long Noncoding RNA Regulating Apoptosis Discovered

from Genetic Engineering News Scientists from the University of São Paulo (USP) have identified an RNA molecule known as INXS that, although containing no instructions for the production of a protein, modulates the action of an important gene that impacts apoptosis. According to Sergio Verjovski-Almeida, Ph.D., professor at the USP Chemistry Institute, INXS expression is generally diminished in cancer cells, ...

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