Monthly Archives: June 2014

RNA regulatory networks in animals and plants: a long noncoding RNA perspective

A recent highlight of genomics research has been the discovery of many families of transcripts which have function but do not code for proteins. An important group is long noncoding RNAs (lncRNAs), which are typically longer than 200 nt, and whose members originate from thousands of loci across genomes. The authors review progress in understanding the biogenesis and regulatory mechanisms ...

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Expression Pattern of Long Non-Coding RNAs in Renal Cell Carcinoma Revealed by Microarray

Recent large-scale transcriptome analyses have found large numbers of transcripts, including that of long non-coding RNAs (lncRNAs), which are aberrant in various diseases, especially cancers. However, it is not clear whether lncRNAs are involved specifically in renal cell carcinoma (RCC). Researchers at the First Affiliated Hospital of Nanjing Medical University investigated the expression patterns of lncRNAs in five RCC tumor ...

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Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of lncRNAs in development and disease. In this review, the authors discuss new findings implicating lncRNAs in controlling development of the central nervous system ...

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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results ...

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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results ...

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Lengthy RNAs earn respect as cellular players

lncRNA

from Science by Elizabeth Pennisi Surveys have uncovered thousands of long non-coding RNAs, molecules longer than 200 bases, and several groups have linked specific ones to development, cancer, pain, inflammation, and much more. There are lingering questions, however, about whether most of these molecules are functional or just spurious byproducts of transcription. At the recent Biology of Genomes meeting, several ...

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lnCeDB: Database of Human Long Noncoding RNA Acting as Competing Endogenous RNA

Long noncoding RNA (lncRNA) influences post-transcriptional regulation by interfering with the microRNA (miRNA) pathways, acting as competing endogenous RNA (ceRNA). These lncRNAs have miRNA responsive elements (MRE) in them, and control endogenous miRNAs available for binding with their target mRNAs, thus reducing the repression of these mRNAs. lnCeDB provides a database of human lncRNAs (from GENCODE 19 version) that can ...

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Upcoming Seminar – Long noncoding RNA: transcription noise or biological modulator? A view from studies in embryonic stem cells

Dr. Xiaohua Shen, Associate Professor Tsinghua University, Beijing, China Wednesday, June 25, 2014 – 11:00am CCBR Red Room Abstract: Pervasive transcription in mammalian genome produces thousands of long noncoding RNA (lncRNA) transcripts. It has been hypothesized that lncRNAs as versatile modulators regulate diverse aspects of biology. However, their biological significance remains skeptical due to healthy concerns of subtle phenotypic differences ...

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Postdoc position available – non-coding RNA research at BRIC, University of Copenhagen

A postdoc position (experienced researcher) is available in the Lund Group at BRIC from October 1st 2014. The position is part of a newly established European non-coding RNA training network, RNAtrain under the FP7 frame programme. The group The Lund group is an international and dynamic research group comprising several postdocs, PhD students and Masters students. Research in the Lund ...

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