Monthly Archives: May 2014

Long non-coding RNAs in lung cancer: comparison of microarray and RNA-seq techniques

from the RNA-Seq Blog PV Nazarov*, T Kaoma, A Muller, S Fritah, L Vallar *Corresponding author: PV Nazarov Genomics Research Unit, CRP-Sante, Luxembourg, Luxembourg F1000Posters 2013, 4: 1446 (poster) [English] – Poster [1.22 MB] Presented at: Benelux Bioinformatics Conference 2013 , 9 – 10 Dec 2013, P82 Affiliated Society: Benelux Bioinformatics Conference Background / Purpose: We compared two experimental approaches ...

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MYC Regulated by Super-Enhancer Long Noncoding RNA in Colorectal Cancer

In the cover story published on May 5th, 2014 in Cell Research, the team led by CHEN Lingling from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, presents a Colorectal Cancer (CRC) specific long noncoding RNA, CCAT1-L, in the regulation of MYC expression across over 500 kb in distance by participating in higher chromatin organization. The expression ...

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Biological and bioinformatical approaches to study crosstalk of long-non-coding RNAs

Long-non-coding RNA (lncRNA) regulates gene expression through transcriptional and epigenetic regulation as well as alternative splicing in the nucleus. In addition, regulation is achieved at the levels of mRNA translation, storage and degradation in the cytoplasm. During recent years, several studies have described the interaction of lncRNAs with enzymes that confer so-called epigenetic modifications, such as DNA methylation, histone modifications ...

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Featured lncRNA – ncRuPAR

lncRNA

ncRuPAR is a newly discovered long noncoding RNA molecule that can upregulate protease-activated receptor-1 (PAR-1) during embryonic growth; however, its role in cancer has not been elucidated. Here, researchers at the Second Military Medical University, China conducted a study to investigate the role of ncRuPAR in gastric cancer. Significant downregulation of ncRuPAR was detected in gastric cancer tissues compared with ...

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Post-doc position available – Computational lncRNA Genomics

Postdoctoral Research Scientist – Computational lncRNA Genomics MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, Oxford Grade 7: £29,837 – £36,661 with a discretionary range to £38,907 p.a. We are seeking a highly motivated and enthusiastic postdoctoral scientist to join Professor Chris Ponting’s research group in the internationally renowned MRC Functional Genomics Unit at the University of Oxford. ...

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Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs

Pieter Mestdagh, Barbara D’haene, Jan Hellemans and Jo Vandesompele biogazelle Currently, expression and function of lncRNAs during human disease and development is largely unexplored. Few platforms are available that allow sensitive and specific high-throughput lncRNA expression profiling. Study concludes, among other things, that lncRNA expression profiling of 60 cancer cell lines representing 9 different tumour entities reveals cancer-specific lncRNA expression ...

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Salk Institute study identifies novel regulator of key gene expression in cancer

Findings may lead to new targets for cancer treatment LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code ...

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Salk Institute study identifies novel regulator of key gene expression in cancer

Findings may lead to new targets for cancer treatment LA JOLLA, CA—Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code ...

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Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)

Goteborg University (PER 2014/201) Title Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)  (PER 2014/201) Advertiser Goteborg University Role Postdoctoral Research Fellow Discipline Medicine & Health Location Gothenburg, Sweden Work Type Full Time, Fixed Term, 2 years Extent: 100 % Location: Institute of Biomedicine, Göteborg First day of employment: As agreed Reference number: PER 2014/201 The Institute of Biomedicine ...

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Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)

Goteborg University (PER 2014/201) Title Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)  (PER 2014/201) Advertiser Goteborg University Role Postdoctoral Research Fellow Discipline Medicine & Health Location Gothenburg, Sweden Work Type Full Time, Fixed Term, 2 years Extent: 100 % Location: Institute of Biomedicine, Göteborg First day of employment: As agreed Reference number: PER 2014/201 The Institute of Biomedicine ...

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