Monthly Archives: March 2014

Research Topic – Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders

Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders Topic Editors: Yingqun Huang, Yale University School of Medicine, American Samoa Romano Regazzi, University of Lausanne, Switzerland William Cho, Queen Elizabeth Hospital, Hong Kong Review Article, Published on 04 Mar 2014 Molecular mechanisms of long ncRNAs in neurological disorders Dubravka Vučićević, Heinrich Schrewe and Ulf Andersson Ørom doi: ...

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Postdoctoral Position: The role of long non-coding RNAs (lncRNAs) in beta-cell health

Reference Number – POSTDOC71 Date Added – 26/03/2014 Country – United Kingdom Location – Molndal SE Career Area  – CVMD GMed Introduction At AstraZeneca we are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca’s commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans ...

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Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson's Leukocytes Identified by RNA Sequencing

Long non-coding RNAs (lncRNAs) comprise a novel, fascinating class of RNAs with largely unknown biological functions. Parkinson’s-disease (PD) is the most frequent motor disorder, and Deep-brain-stimulation (DBS) treatment alleviates the symptoms, but early disease biomarkers are still unknown and new future genetic interference targets are urgently needed. Using RNA-sequencing technology and a novel computational workflow for in-depth exploration of whole-transcriptome ...

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Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures

Inappropriate transcriptional activation of innate immunity is a pathological feature of several cardiometabolic disorders, but little is known about inflammatory modulation of long intergenic noncoding RNAs (lincRNAs) in disease-relevant human tissues. Researchers at the University of Pennsylvania applied deep RNA sequencing (>500 million filtered reads per sample) to blood and adipose during low-dose experimental endotoxemia (lipopolysaccharide) in a healthy human, ...

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Natural Antisense Transcripts and Long Non-Coding RNA in Neurospora crassa

lncRNA

The prevalence of long non-coding RNAs (lncRNA) and natural antisense transcripts (NATs) has been reported in a variety of organisms. While a consensus has yet to be reached on their global importance, an increasing number of examples have been shown to be functional, regulating gene expression at the transcriptional and post-transcriptional level. Here, researchers at the University of Manchester use ...

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Missing links in cardiology: long non-coding RNAs enter the arena

Heart failure as a consequence of ischemic, hypertensive, infectious, or hereditary heart disease is a major challenge in cardiology and topic of intense research. Recently, new players appeared in this field and promise deeper insights into cardiac development, function, and disease. Long non-coding RNAs are a novel class of transcripts that can regulate gene expression and may have many more ...

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The four dimensions of noncoding RNA conservation

Evolutionary conservation is widely used as an indicator of the functional significance of newly discovered genes. Although the simple search for homology at the nucleotide or amino acid sequence level has proven to be valuable for protein-coding genes, these criteria are too narrow to describe fully the selection process for long noncoding RNAs (lncRNAs). LncRNA conservation includes four dimensions: the ...

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Featured long non-coding RNA – PCAT-1

lncRNA

Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, although mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, a team led by researchers at the Michigan Center for Translational Pathology describes the first role for a long noncoding RNA (lncRNA) in DSB ...

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Non-coding RNA interact to regulate neuronal development and function

The human brain is one of the most complex biological systems, and the cognitive abilities have greatly expanded compared to invertebrates without much expansion in the number of protein coding genes. This suggests that gene regulation plays a very important role in the development and function of nervous system, by acting at multiple levels such as transcription and translation. In ...

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