Monthly Archives: February 2014

Regulatory non-coding RNAs: revolutionizing the RNA world

The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, the authors review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight ...

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Systematically profiling and annotating long intergenic non-coding RNAs

While more and more long intergenic non-coding RNAs (lincRNAs) were identified to take important roles in both maintaining pluripotency and regulating differentiation, how these lincRNAs may define and drive cell fate decisions on a global scale are still mostly elusive. Systematical profiling and comprehensive annotation of embryonic stem cells lincRNAs may not only bring a clearer big picture of these ...

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Boston area is leading RNA renaissance

Science is leaping forward, and investors are watching closely from the Boston Globe By  Robert Weisman After several years of waning enthusiasm for an approach to drug-making that was once called revolutionary, interest in RNA medicines is suddenly on the upswing, and Boston area start-ups are at the front of the resurgence. The field got a high-octane boost last week ...

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Featured long non-coding RNA – Pldi

lncRNA

The gene Polymorphic derived intron-containing, known as Pldi, is a long non-coding RNA (lncRNA) first discovered in mouse. Although parts of its sequence were reported to be conserved in rat and human, it can only be expressed in mouse testis with a mouse-specific transcription start site. The consensus sequence of Pldi is also part of an antisense transcript AK158810 expressed ...

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Unexpected functions of lncRNAs in gene regulation

Long non-coding RNAs (lncRNAs) are a group of molecules that function in gene regulation in yeast, plants and mammals. The precise mechanisms of action for lncRNAs, however, remain largely unclear. The GAL gene cluster has been used as a model system to study the function of these molecules in Saccharomyces cerevisiae, with a historical focus on lncRNA-dependent repression. Strikingly, in ...

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Long noncoding RNAs in innate and adaptive immunity

lncRNA

The differentiation and activation of both innate and adaptive immune cells is highly dependent on a coordinated set of transcriptional and post-transcriptional events. Chromatin-modifiers and transcription factors regulate the accessibility and transcription of immune genes, respectively. Immune cells also express miRNA and RNA-binding proteins that provide an additional layer of regulation at the mRNA level. However, long noncoding RNAs (lncRNAs), ...

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Long non-coding RNAs help genes get out of the starting blocks faster

lncRNA

from Imperial Valley News West Lafayette, Indiana – Yeast can quickly adapt to changes in its environment with the help of molecules known as long non-coding RNAs, a Purdue study shows. Elizabeth Tran, assistant professor of biochemistry, and her fellow researchers found that long non-coding RNAs prepare metabolic genes to be activated swiftly when baker’s yeast needs to switch its ...

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Featured Long-noncoding RNA – linc00467

The worst subtype of neuroblastoma is caused by MYCN oncogene amplification and N-Myc oncoprotein over-expression. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and tumourigenesis. While Myc oncoproteins are well-known to exert tumourigenic effects by regulating the expression of protein-coding genes and microRNAs, little is known about which lncRNAs are Myc targets and whether the Myc ...

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RNAi 2014: Short & Long Non-coding RNAs

9th International Conference & Exhibition 25-27 March 2014 St Hilda’s College, Oxford, UK The 9th Annual Oxford RNAi Conference, RNAi2014, will discuss short and long non-coding RNAs, their roles in gene regulation, functional studies, RNA biomarkers and their therapeutic applications. Considerable attention will be given to chemical design and in vitro and in vivo delivery strategies for small RNAs. Key topics to be covered include: ...

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Featured long non-coding RNA – Antisense Sirt1

Natural antisense transcripts (NATs) exist ubiquitously as pivotal molecules to regulate coding gene expression. Sirtuin 1 (Sirt1) is a NAD-dependent deacetylase which is involved in myogenesis. However, whether Sirt1 transcribes NAT during C2C12 differentiation is still unknown. In this study, researchers at Northwest A&F University, China identified a Sirt1 NAT which was designated as Sirt1 antisense long non-coding RNA (AS ...

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