Monthly Archives: January 2014

RaNA Therapeutics Raises $20.7 Million to Harness the Potential of Long Non-coding RNA

CAMBRIDGE, Mass.–(BUSINESS WIRE)–RaNA Therapeutics, Inc. today announced it has completed a $20.7 million round of financing co-led by Atlas Venture, SR One, and Monsanto, with participation of Partners Innovation Fund. The company is developing a technology platform to enable selective activation of target genes and expression of therapeutic factors by targeting a type of regulatory RNA called long non-coding RNA. ...

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Integrating the roles of long and small non-coding RNA in brain function and disease

lncRNA

Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in the mammalian brain. While the protein machinery has remained largely constant throughout animal evolution, the non protein-coding transcriptome has expanded considerably to provide essential and widespread cellular regulation, partly through directing generic protein function. Both long (long non-coding RNA) and small non-coding RNAs (for example, microRNA) ...

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The evolution of lncRNA repertoires and expression patterns in tetrapods

lncRNA

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here researchers at the University of Lausanne, Switzerland present a large-scale evolutionary study of lncRNA repertoires and expression patterns, in 11 tetrapod species. ...

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X-inactivation: xist RNA uses chromosome contacts to coat the X

The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action. In organisms with XY sex chromosomes, chromatin modifications are directed to the X chromosomes (X) to equalize X-linked ...

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Long non-coding RNA UCA1 promotes breast tumor growth

lncRNA

Functional genomics studies have led to the discovery of a large amount of non-coding RNAs from the human genome; among them are long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs could have a critical role in the regulation of cellular processes such as cell growth and apoptosis as well as cancer progression and metastasis. As master gene regulators, lncRNAs ...

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Transcriptomics to Therapeutics: Bridging the lncRNA Divide

Kip Harry Life Science Professional Join a focused discussion group on the therapeutic potential of lncRNA, addressing the following questions: Have exomes and RNA-Seq hindered, rather than helped, lncRNA disease genomics? How can we proceed from disease lncRNA discovery, in GWAS and functional studies, to translational therapeutics? Which of the currently known lncRNA mechanisms present the best opportunities for therapeutic ...

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Now it is lncRNA That Goes From Junk to Hero

“The brain likes this junk RNA” Dan Graur’s doubling down on evolution (either our genome is mostly junk or evolution is false) took yet another hit this month with a Harvard group showing that it is now lncRNA’s turn at the “I guess it isn’t junk after all” meme. The Harvard scientists selectively removed different so-called long intergenic noncoding RNA ...

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Long Non-Coding RNA H19 Promotes Glioma Cell Invasion by Deriving miR-675

lncRNA

H19 RNA has been characterized as an oncogenic long non-coding RNA (lncRNA) in breast and colon cancer. However, the role and function of lncRNA H19 in glioma development remain unclear. In this study, scientists from the First Affiliated Hospital of Nanjing Medical University identified that H19/miR-675 signaling was critical for glioma progression. By analyzing glioma gene expression data sets, they ...

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Featured long noncoding RNA – THRIL

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, researchers from the Sanford-Burnham Medical Research Institute used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was found to be differentially ...

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Knockout Mice Study: Long Noncoding RNAs "Play Central Roles in Mammalian Development and Physiology"

lncRNA

by Casey Luskin at Evolution News & Views A few years ago I wrote about challenges to the claim that “junk DNA” wasn’t necessary for development. In experiments with mice, researchers had supposedly “knocked out” non-coding DNA, yet the mice themselves as they grew turned out to be healthy. Now a new study in eLife, “Multiple knockout mouse models reveal ...

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