Monthly Archives: December 2013

NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MENε/β long noncoding RNA (lncRNA). Here a team led by researchers at Hokkaido University, Japan show that paraspeckles become dramatically enlarged after proteasome inhibition. This enlargement is mainly caused by NEAT1 transcriptional up-regulation rather than accumulation of undegraded paraspeckle proteins. Of interest, however, using immuno–electron microscopy, we find that ...

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The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL

lncRNA

Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, a team led by researchers at the Sanford-Burnham Medical Research Institute used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincRNAs was ...

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A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer

lncRNA

In recent years, long non-coding RNAs (lncRNAs) have been investigated as a new class of regulators of cellular processes, such as cell growth, apoptosis, and carcinogenesis. Although lncRNAs are dysregulated in numerous cancer types, limited data are available on the expression profile and functional role of lncRNAs in non-small cell lung cancer (NSCLC). In the present study, researchers at the ...

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Featured long non-coding RNA Job – Research Scientist or a Postdoctoral Researcher – RIKEN

Seeking Either a Research Scientist or a Postdoctoral Researcher RIKEN Genome Information Analysis Team, Life Science Accelerator Technology Group, Division of Genomic Technologies, Center for Life Science Technologies : Yokohama, Japan Laboratory Genome Information Analysis Team, Life Science Accelerator Technology Group, Division of Genomic Technologies, RIKEN Center for Life Science Technologies (Team Leader: Alistair FORREST) Research Field The RIKEN Center ...

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Emerging epigenetic mechanisms of long non-coding RNAs

lncRNA

Long non-coding RNAs (lncRNAs) have been increasingly appreciated as an integral component of gene regulatory networks. Genome-wide features of their origin and expression patterns ascribed a prominent role for lncRNAs to the regulation of protein-coding genes, and also suggest a potential link to many human diseases. Recent studies have begun to unravel the intricate regulatory mechanism of lncRNAs occurring at ...

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Featured long non-coding RNA job – Assistant Scientist

University of Florida Job Location: Gainesville, FL Job Category: Chemistry / biochemistry Posted: December 17 Applicants who have a PhD degree and 5 years postdoctoral training in the area of Biochemistry and Molecular Biology with special expertise in long-noncoding RNA function, Chromatin Biology, and Insulator function are encouraged to apply. Investigating trithorax group complex function in hematopoietic commitment and differentiation. ...

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Scientists home in on a short list of interesting RNA ‘machines.’

lncRNA

Computer models plus observations of RNA inside a cell help scientists home in on a short list of interesting RNA ‘machines.’ by Elizabeth Dougherty, MIT News correspondent DNA stores the information of life, proteins provide the action, and in between sits elusive RNA, which serves both as a database of information and as a molecular machine. RNA is more flexible ...

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RNA and protein molecules join forces to switch on gene networks responsible for brain development

lncRNA

from Medical Xpress Long noncoding RNAs (lncRNAs) are one of many RNA subtypes that do not give rise to protein but instead modulate the expression of other genes. Scientists are particularly interested in lncRNAs owing to their prominent role in regulating how embryonic stem cells give rise to mature tissues. Lawrence Stanton and colleagues at the A*STAR Genome Institute of ...

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Featured Long non-coding RNA – Hotair

Yoon JH, Abdelmohsen K, Kim J, Yang X, Martindale JL, Tominaga-Yamanaka K, White EJ, Orjalo AV, Rinn JL, Kreft SG, Wilson GM, Gorospe M. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Nat Commun. 2013 Dec 11;4:2939. doi: 10.1038/ncomms3939. Wu L, Murat P, Matak-Vinkovic D, Murrell A, Balasubramanian S.The binding interaction between long non-coding RNA HOTAIR and PRC2 ...

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Tackling Structures of Long Noncoding RNAs

lncRNA

RNAs are important catalytic machines and regulators at every level of gene expression. A new class of RNAs has emerged called long non-coding RNAs, providing new insights into evolution, development and disease. Long non-coding RNAs (lncRNAs) predominantly found in higher eukaryotes, have been implicated in the regulation of transcription factors, chromatin-remodeling, hormone receptors and many other processes. The structural versatility ...

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